Overview
2-Hydroxy-5-nitro nicotinic acid is a nitro-substituted derivative of nicotinic acid, primarily used as an intermediate in pharmaceutical and agrochemical synthesis. Its molecular structure combines a hydroxyl group and a nitro group on a pyridine ring, making it a versatile building block for heterocyclic compounds. This compound is typically synthesized through nitration reactions of hydroxylated nicotinic acid derivatives. Its applications are largely confined to research and development, where it serves as a precursor for more complex molecules in medicinal chemistry.
Physical and Chemical Properties
The compound appears as a yellow to light brown crystalline powder, with moderate solubility in polar organic solvents like dimethyl sulfoxide (DMSO) and limited solubility in water. Its molecular weight is 184.11 g/mol, and its stability is influenced by storage conditions, requiring protection from light and moisture. Key chemical properties include its reactivity as a nitro-aromatic compound, which can participate in reduction and substitution reactions. The presence of both hydroxyl and nitro groups on the pyridine ring allows for diverse functionalization, making it valuable in synthetic chemistry.
Main Applications
2-Hydroxy-5-nitro nicotinic acid is predominantly used in pharmaceutical research as an intermediate for drug discovery, particularly in the synthesis of antibacterial and anti-inflammatory agents. Its nitro group can be reduced to an amine, enabling further derivatization. In agrochemicals, it serves as a precursor for herbicides and pesticides. The compound’s heterocyclic structure aligns with bioactive molecules targeting plant pathogens. However, commercial-scale applications are limited compared to its research use.
Safety and Storage
Due to its nitro group, the compound may pose explosive risks under extreme conditions (e.g., high heat or shock). Standard laboratory precautions, including gloves and goggles, are mandatory. Avoid inhalation of dust and ensure adequate ventilation. Storage should be in tightly sealed containers, away from light and moisture, at room temperature or below. Labeling must comply with chemical safety regulations, and disposal should follow local guidelines for nitro-aromatic waste.
B2B Procurement Guide
When procuring 2-hydroxy-5-nitro nicotinic acid, prioritize suppliers with certifications like ISO or GMP, especially for pharmaceutical-grade material. Request detailed purity analysis (HPLC or NMR) and batch-specific COAs (Certificates of Analysis). Bulk pricing is often negotiable, but pilot-scale quantities (100g–1kg) are commonly sold for research. Lead times vary; ensure supplier reliability for consistent quality. Consider logistics for temperature-sensitive transport if required.
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