Overview
2-Hydroxy-5-nitroacetophenone is a nitrated phenolic ketone primarily used as an intermediate in pharmaceutical and chemical synthesis. Its molecular structure features both a hydroxyl and a nitro group, making it reactive for various organic transformations. This compound is commonly employed in the production of active pharmaceutical ingredients (APIs) and specialty dyes. Its yellow crystalline form and solubility in organic solvents make it suitable for laboratory and industrial applications.
Physical and Chemical Properties
2-Hydroxy-5-nitroacetophenone is characterized by its yellow crystalline appearance and a molecular weight of 181.15 g/mol. It has a melting point range of 130-132°C, indicating moderate thermal stability. The compound is soluble in ethanol, acetone, and other polar organic solvents but has limited solubility in water. Its reactivity is influenced by the presence of both the hydroxyl and nitro groups, which participate in electrophilic and nucleophilic reactions.
Main Applications
This chemical is widely used as an intermediate in the synthesis of pharmaceuticals, particularly in the development of antibacterial and anti-inflammatory drugs. Its nitro group makes it valuable for further functionalization. Additionally, 2-Hydroxy-5-nitroacetophenone finds applications in dye manufacturing, where it serves as a precursor for nitro-substituted dyes. Its versatility in organic synthesis also extends to agrochemicals and specialty chemicals.
Safety and Storage
Handling 2-Hydroxy-5-nitroacetophenone requires caution due to its potential irritant properties. Proper personal protective equipment (PPE), including gloves and goggles, is recommended to avoid skin or eye contact. Storage should be in a cool, dry environment, protected from light and moisture to prevent degradation. Containers must be tightly sealed to avoid contamination and ensure long-term stability.
B2B Procurement Guide
When procuring 2-Hydroxy-5-nitroacetophenone, prioritize suppliers with documented quality control measures. Verify the compound's purity through certificates of analysis (CoA) and ensure compliance with regional regulations. Bulk purchases may offer cost advantages, but storage capacity and shelf-life considerations should be evaluated. Establish clear communication with suppliers regarding lead times, packaging options, and transportation requirements.
Related Manufacturers
- 主营：阻燃剂、乙酸镍、乙酸镝、羟基、硫酸锂、硫酸锶、溴氨酸、香茅醇、肌氨酸、锂电池、四氢萘、磷酸铬、碳酸镁、碳酸镍、防冻剂、磷酸铝、叔丁醇、氟苯基、浮选剂、稀释剂、羟乙基、去除剂、庚二酸、除磷剂、十八烯、蛋白酶
- 主营：甜菊糖、氯乙酰、二乙苯、4861-19-2、1192-62-7、8002-74-2、7782-61-8、2842-44-6、1310-58-3、酞菁绿、阻燃剂、4316-73-8、二戊烯、单甲醚、硫酸锂、大理石、羊脂酸、7783-40-6、磷酸氢、龙脑油、聚甘油、二聚酸、戊二醇、聚醚f68、磺化油
- 主营：硼酸酐、阻聚剂、己二酸、羟基、氯化锂、发泡剂、乙二醇、醋酸铜、硅酸钠、正癸醇、新癸酸、环烷油、腰果酚、十二醇、酒石酸、碳酸锂、三甘醇、油菜酸、二甘醇、碳酸钾、甲酸钠、硅酸镁、棕榈油、6-氯嘌呤、微晶石蜡、磷酸一铵
- 主营：乙二醇、二甲基亚砜、丙二醇、羟基、精对苯二甲酸、己二酸、聚乙烯醇、聚乙二醇、木质素、甘油、三甘醇、己内酰胺、叔十二硫醇、白油、对苯二甲酸二甲酯、4-丁二醇
- 主营：甲硫醇钠、甲基磺酸、六氟磷酸钠、羟基、碳酸二甲酯、3-吡啶二甲酸、环己基苯、六氟磷酸钾、N-二甲基正辛胺
- 主营：棕榈酸、乙酸铋、异喹啉、2-乙二硫醇、胶粘剂、丙烯酸酯、化学试剂、分析试剂、透明液体、二乙二醇、光引发剂、岩白菜素、对甲苯磺酸、苯甲酸苄酯、偏苯三酸酐、六氟异丙醇、纳米氧化铽、六氟磷酸铯、表面活性剂、蓖麻醇酸锌、乙基纤维素、荧光指示剂、4-二氟苄溴|、丙烯酸羟乙酯、3-丙烷磺内酯
- 主营：山梨酸钾、吡唑啉酮、清凉茶酸、羟基嘧啶、山梨酸钙、磺酸苯基、叔丁基锂、双乙烯酮、基氨基锂、氯乙酰氯、三正丁基、四羟甲基、乙酰苯胺、甲基苯基、氯羟吡啶、硫酸磷脲
- 主营：苯乙酮、硫磺粉末
- 主营：三聚甲醛、四甲基氢氧化胺、双季戊四醇、苯乙酮、双乙烯酮、异丙叉丙酮、十一烷、硫氢化钠、甲基丙烯酸十八酯、四甲基氢氧化铵五水合物、水杨羟肟酸、异己二醇、苯甲羟肟酸、聚硫橡胶、甲基纤维素、环氧环己烷、硬脂酸乙二醇单酯、邻氯溴苯、二苯甲酮BP、氨基磺酸、均苯四甲酸二酐、月桂酸钠、吐温、司盘
- 主营：17746-77-9、三癸基铝、甲氧苯基、625392-06-5、1423716-55-5、1547041-34-8、8-二羟基萘、磺胺曲沙唑、三十二烷基铝、甲氧基苯甲酸、4-氯嘧啶盐酸盐
- 主营：5-溴-7-氮杂吲哚、柠檬酸钠、液体溴化钙
- 主营：苯乙酮、萃取剂、选矿药剂、金矿硫化矿
- 主营：涂料助剂、工业清洗剂、表面活性剂、羟基、合成材料助剂、合成香料、溶剂、香精和香料中间、合成材料中间体、选矿药剂、萃取剂
- 主营：苯乙酮、杂环化合物、丙烯酸系列
- 主营：乙醛酸、铁甲酸、二甲基、2-羟基喹喔啉、2-苯并唑啉酮、对羟基苯海因、2-氨基-5-氯苯酚、羟乙基、草酰胺、3-氯丙炔、邻苯二甲、苯甲酰胺、溴氯海因、3-氯水扬酸、磷酸三甲酯、3-环戊二羧酸、6-二氯异烟酸