Overview
2'-Hydroxy-5'-methylacetophenone is a phenolic ketone derivative with a molecular formula of C9H10O2. It serves as a versatile intermediate in organic synthesis, particularly in pharmaceuticals and specialty chemicals. The compound's hydroxyl and acetyl functional groups enable reactions such as esterification and etherification, making it valuable for synthesizing complex molecules. Industrially, it is produced through Friedel-Crafts acylation of cresols or related processes. Its applications span UV stabilizers, photoinitiators, and fragrance components due to its aromatic structure. Regulatory compliance (e.g., REACH, FDA for specific uses) should be confirmed before large-scale procurement.
Physical and Chemical Properties
This compound appears as an off-white to pale yellow crystalline powder with a melting point range of 52-56°C. It is soluble in common organic solvents like ethanol and ether but has limited solubility in water. The hydroxyl group contributes to its polarity and reactivity, while the methyl and acetyl groups influence its volatility and stability. Key chemical properties include its ability to form hydrogen bonds and participate in electrophilic substitution reactions. Storage stability is moderate; it should be protected from prolonged exposure to light and moisture to prevent degradation. Analytical methods like HPLC and GC-MS are typically used for purity verification.
Main Applications
In pharmaceuticals, 2'-Hydroxy-5'-methylacetophenone is a precursor for active pharmaceutical ingredients (APIs), including anti-inflammatory and antimicrobial agents. Its structural motif is found in several drug molecules, leveraging its phenolic and ketone functionalities. The fragrance industry utilizes it as a building block for floral and woody scent compounds. Additionally, it acts as a UV absorber in coatings and plastics, where its ability to quench free radicals enhances material durability. Emerging applications include agrochemicals and advanced polymer additives, though these are niche markets.
Safety and Storage
Handle with care: the compound may cause skin and eye irritation, and inhalation of dust should be avoided. PPE such as nitrile gloves and safety goggles is recommended. Ensure workplaces are well-ventilated, and use local exhaust if handling powders. Store in tightly sealed containers under inert conditions (e.g., nitrogen atmosphere) to prevent oxidation. Shelf life is typically 2-3 years when stored below 25°C. Dispose of waste according to local hazardous material regulations, avoiding release into waterways.
B2B Procurement Guide
Buyers should prioritize suppliers with ISO certification and batch-specific Certificates of Analysis (CoA). Key specifications to verify include purity (≥98% for most applications), residual solvent levels, and heavy metal content. Bulk orders (25kg drums or larger) often reduce costs by 10-20%. Logistics require temperature-controlled transport if ambient temperatures exceed 30°C. For international shipments, ensure compliance with customs regulations (e.g., TSCA in the US, IECSC in China). Sample testing via third-party labs is advised for new suppliers.
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