Overview
2-Hydroxy-4-nitroacetophenone is an organic compound primarily used as an intermediate in chemical synthesis. It features a nitro group and a hydroxyl group attached to an acetophenone backbone, making it valuable in pharmaceutical and dye industries. This compound is synthesized through nitration of 2-hydroxyacetophenone, yielding a yellow crystalline powder. Its reactivity and functional groups allow for further derivatization, making it a versatile building block in organic chemistry.
Physical and Chemical Properties
2-Hydroxy-4-nitroacetophenone is a yellow crystalline solid with a molecular weight of 181.15 g/mol. It has a melting point of 95-97°C and is soluble in common organic solvents like ethanol and acetone. The presence of both hydroxyl and nitro groups contributes to its reactivity. It can participate in electrophilic substitution reactions and serve as a precursor for more complex molecules. Its solubility in water is limited, but it dissolves well in polar organic solvents.
Main Applications
This compound is widely used in the synthesis of pharmaceuticals, particularly as an intermediate for active pharmaceutical ingredients (APIs). Its nitro group can be reduced to an amine, enabling further functionalization. In addition to pharmaceuticals, 2-hydroxy-4-nitroacetophenone is employed in dye manufacturing, where its structure contributes to color-forming reactions. It is also used in research laboratories for organic synthesis projects.
Safety and Storage
2-Hydroxy-4-nitroacetophenone should be handled with care due to its potential irritant properties. Proper personal protective equipment (PPE), including gloves and goggles, is recommended during handling. Storage should be in a cool, dry place, away from incompatible substances like strong oxidizers. Containers must be tightly sealed to prevent moisture absorption and degradation.
B2B Procurement Guide
When procuring 2-hydroxy-4-nitroacetophenone, buyers should prioritize suppliers with a proven track record in chemical manufacturing. Purity levels (typically 98% or higher) should be verified via certificates of analysis (CoA). Bulk purchases may offer cost advantages, but storage capacity and shelf life should be considered. Compliance with regional chemical regulations (e.g., REACH, TSCA) is essential for international transactions.
Related Manufacturers
- 主营：苯乙酮、二氟(dfa)乙酸、二氟氯乙酸钠、高性价比苯甲脒
- 主营：黑檀醇、丙烷三、龙涎酮、7-羟基香豆素、4-氟苯肼盐酸盐、丁酸己酯、丙烯酸酯、茉莉内酯、三羟甲基、二乙氨基乙醇、半胱胺盐酸盐、乙基乙烯基醚、叔丁基对苯二酚、优级支链烷基苯
- 主营：苯乙酮、双草酸酯、二茂铁甲醛
- 主营：石竹素、中间体、邻氟氯苄、反-查耳酮、2-甲基哌嗪、2-糠酸甲酯、2-噻吩甲醛、2-乙基咪唑、2-甲氧基丙烯、8-萘内酰亚胺、2-呋喃甲酸甲酯、4'-联苯二羧酸、偏钒酸钠、油酸甲酯、油酸乙酯、高藜芦胺、氯碘甲烷、四甲酸二酐、萘二甲酰亚胺、对二甲氨基甲苯
- 主营：顺-6-壬烯-1-醇
- 主营：乙醛酸、铁甲酸、二甲基、3-氯丙炔、3-氯水扬酸、2-羟基喹喔啉、2-苯并唑啉酮、对羟基苯海因、3-环戊二羧酸、6-二氯异烟酸、2-氨基-5-氯苯酚、羟乙基、草酰胺、邻苯二甲、苯甲酰胺、溴氯海因、磷酸三甲酯
- 主营：三癸基铝、甲氧苯基、磺胺曲沙唑、17746-77-9、625392-06-5、1423716-55-5、1547041-34-8、8-二羟基萘、4-氯嘧啶盐酸盐、三十二烷基铝、甲氧基苯甲酸
- 主营：阻聚剂、辛二醇、四甲基、3-二羟基萘、催化剂、十油酸酯、有机合成、硅化合物、光引发剂、十二酸己酯、月桂酸己酯、生物缓冲剂、表面活性剂、硫代卡巴肼、氨基甲酰甲基
- 主营：异硫氰酸胍、三(羟甲基)氨基甲烷tris、二硫苏糖醇(DTT)、苯乙酮、β巯基乙醇、蛋白酶k、焦碳酸二乙酯DEPC、EDTA二钠、十二烷基苯磺酸钠
- 主营：正辛胺、柠檬酸、尿嘧啶、15397-15-6、119736-16-2、4-嘧啶酮、923289-21-8、152628-02-9、2346620-55-9、抗皱素、绿原酸、异丁基、三辛胺、双醚芴、姜黄素、角鲨烯、精磺胺、蒜氨酸、九甘醇、氟苯基、苯甲酰胺、比卡鲁胺、四氢嘧啶、氨基二环、麦角硫因
- 主营：苯肼、氯甲基苯乙烯、无水氯化锂、邻硝基苯磺酰氯、4-二氢吡喃、4-溴靛红、四羟基二硼、丙酰乙酸甲酯、碘甲烷、亚磷酸三苯酯、苯并噻唑、苄胺、苯基锂、叔丁醇钾、三丁基膦