2-Fluorobiphenyl
Overview
2-Fluorobiphenyl is an aromatic organic compound with a fluorine atom substituted at the ortho position of a biphenyl structure. It is widely used as a building block in pharmaceutical and agrochemical industries due to its ability to introduce fluorine into more complex molecules. The compound is synthesized through cross-coupling reactions or fluorination processes. Its stability and reactivity make it a valuable intermediate in organic synthesis, particularly in the development of active pharmaceutical ingredients (APIs) and specialty chemicals.
Physical and Chemical Properties
2-Fluorobiphenyl is a colorless to pale yellow liquid with a characteristic aromatic odor. It has a density of approximately 1.06 g/cm³ and a boiling point around 225-227°C. The compound is soluble in common organic solvents like ethanol, ether, and acetone but exhibits negligible solubility in water. Chemically, 2-fluorobiphenyl is relatively stable under normal conditions. However, it may decompose when exposed to high temperatures or strong oxidizing agents, releasing toxic fumes such as hydrogen fluoride. The fluorine atom at the ortho position influences its reactivity, making it useful in various substitution and coupling reactions.
Main Applications
The primary application of 2-fluorobiphenyl is as an intermediate in the pharmaceutical industry. It is used in the synthesis of various drugs, including anti-inflammatory and antiviral medications. The fluorine atom enhances the biological activity and metabolic stability of the final pharmaceutical compounds. In agrochemicals, 2-fluorobiphenyl serves as a precursor for herbicides and fungicides. Its role in organic synthesis extends to materials science, where it is used to create fluorinated polymers and liquid crystals. The compound's versatility makes it a critical component in specialty chemical manufacturing.
Safety and Storage
2-Fluorobiphenyl should be handled with care due to its potential health hazards. Direct contact can cause skin and eye irritation, while inhalation of vapors may lead to respiratory discomfort. Proper personal protective equipment (PPE), including gloves and goggles, is essential when working with this chemical. Storage conditions should include a cool, dry, and well-ventilated area, away from heat sources and open flames. Containers must be tightly sealed to prevent leakage and contamination. In case of spills, absorb the material with an inert substance and dispose of it according to local regulations.
B2B Procurement Guide
When procuring 2-fluorobiphenyl, buyers should prioritize suppliers with a proven track record of quality and compliance. Key considerations include verifying the CAS number (321-60-8) and ensuring the product meets the required purity specifications, typically 98% or higher. Bulk procurement may offer cost advantages, but buyers should also evaluate logistics and storage capabilities. It is advisable to request safety data sheets (SDS) and certificates of analysis (CoA) from suppliers. Establishing long-term partnerships with reliable manufacturers can ensure consistent supply and competitive pricing.
Related Manufacturers
- 主营：聚乙二醇、聚丙二醇、叔胺、伯胺、染料中间体
- 主营：硼酸酐、阻聚剂、己二酸、6-氯嘌呤、氯化锂、发泡剂、乙二醇、醋酸铜、硅酸钠、正癸醇、新癸酸、环烷油、腰果酚、十二醇、酒石酸、碳酸锂、三甘醇、油菜酸、二甘醇、碳酸钾、甲酸钠、硅酸镁、棕榈油、微晶石蜡、磷酸一铵
- 主营：聚丙烯酰胺、聚合氯化铝、片碱、溴2、纯碱、硫酸亚铁、磷酸、元明粉、乙二醇、工业盐、次氯酸钠
- 主营：阻燃剂、乙酸镍、乙酸镝、十氟联苯、硫酸锂、硫酸锶、溴氨酸、香茅醇、肌氨酸、锂电池、四氢萘、磷酸铬、肉桂醇、碳酸镁、碳酸镍、防冻剂、磷酸铝、叔丁醇、氟苯基、浮选剂、稀释剂、羟乙基、去除剂、庚二酸、除磷剂、十八烯
- 主营：单辛酸甘油酯、三硫代碳酸钠、辛酸镁盐、4-D钠盐、N-甲基硫脲、N-甲基吡咯烷酮、N-甲基邻氨基苯甲酸甲酯、8-辛二醇、菜籽油甲酯、羟丙基纤维素、硫酸烟酰苯胺、离子液体、咪唑、表面活性剂、光引发剂、紫外线吸收剂、UV单体
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：氟联苯生产企业、阿昔洛韦侧链、化工原料
- 主营：吡啶盐酸盐
- 主营：蓬松剂、异辛醇、化妆品、n-甲基吡咯烷酮、异辛酸、护发素、二乙二醇、反应试剂、双羟乙基、三乙醇胺、苯磺酸钠、粘合剂涂料、酰胺丙基三、表面活性剂、三甲基氯化铵、阳离子纤维素、甲基葡萄糖苷
- 主营：321、分析纯试剂
- 主营：硫酸烟酰苯胺、聚苯胺、硫酸阿托品、N-油酰肌氨酸、表面活性剂、光引发剂、离子液体、乙基纤维素、缓蚀剂、OB酸
- 主营：环戊酮、甲酸镍、阻燃剂、氟联苯、草酸镧、钼酸铵、催化剂、钒酸铋、溴氨酸、硝酸锆、碳酸镧、白僵菌、磷酸铁、钨酸酐、氟化镧、视黄醇、叔丁醇、杀螨剂、杀虫剂、醋酸钬、抗粘剂、氟化镥、肟菌酯、氢化钠、氯铂酸、氟化镁
- 主营：橡胶油、白芷油、pbtcaona4、7782-92-5、2905-60-4、5989-81-1、1305-62-0、1192-62-7、9005-32-7、7775-27-1、8050-09-7、1739-84-0、7786-30-3、6920-22-5、1897-52-5、7727-21-1、艾叶油、二甲基、桉树醇、重质苯、活性炭、安息油、正辛烷、黄糊精、三辛胺
- 主营：三羟甲基氨基甲烷、乙酰苯肼、异硫氰酸胍、4-二甲氨基吡啶、N-乙烯基己内酰胺、4-羟乙基哌嗪乙磺酸、PPS-OH、N-羟基丁二酰亚胺、8-羟基喹啉硫酸盐、盐酸胍、吡唑、AMPS、对三氟甲基苯甲酸、PTSA 荧光示踪剂、二氢茉莉酸丙酯、正丁基硫代磷酸三胺、对氟苯甲酸、呋虫胺、三聚硫氰酸三钠盐、ODPA、丙环唑、噻苯隆、噻菌灵、甲基纳迪克酸酐、DMPP
- 主营：山梨酸钾、羟基嘧啶、吡唑啉酮、氟联苯、清凉茶酸、山梨酸钙、磺酸苯基、叔丁基锂、双乙烯酮、基氨基锂、氯乙酰氯、三正丁基、四羟甲基、乙酰苯胺、甲基苯基、氯羟吡啶、硫酸磷脲