Overview
2-Fluoro-4-bromophenol is a halogenated phenol derivative widely used as a building block in organic synthesis. Its molecular structure combines a hydroxyl group with fluorine and bromine substituents, making it a versatile intermediate for pharmaceuticals and agrochemicals. The compound is typically synthesized through halogenation reactions of phenol derivatives. Due to its reactive functional groups, 2-Fluoro-4-bromophenol is valuable for introducing fluorine and bromine moieties into more complex molecules. It is commonly employed in cross-coupling reactions and as a precursor for active pharmaceutical ingredients (APIs).
Physical and Chemical Properties
2-Fluoro-4-bromophenol appears as a white to pale yellow crystalline solid with a characteristic phenolic odor. It has a molecular weight of 191.00 g/mol and is moderately soluble in polar organic solvents. The presence of both fluorine and bromine atoms influences its reactivity and stability. The compound's melting point ranges between 50-60°C, though exact values may vary based on purity. Its solubility in water is limited, but it dissolves readily in alcohols, ethers, and chlorinated solvents. The hydroxyl group makes it slightly acidic, capable of forming salts with strong bases.
Main Applications
This chemical serves as a key intermediate in the synthesis of various pharmaceuticals, including antiviral and antibacterial agents. Its halogen atoms enable further functionalization through reactions like Suzuki coupling or nucleophilic aromatic substitution. In agrochemicals, 2-Fluoro-4-bromophenol is used to produce herbicides and pesticides with enhanced activity. Additionally, it finds applications in material science for creating specialty polymers and liquid crystals. Research laboratories also utilize it for developing novel organic compounds with tailored properties.
Safety and Storage
2-Fluoro-4-bromophenol requires careful handling due to its potential health hazards. It can cause skin irritation, eye damage, and respiratory discomfort upon exposure. Always use gloves, goggles, and protective clothing when working with this compound. Store the chemical in a tightly sealed container under cool, dry conditions, away from oxidizing agents and strong bases. Proper ventilation is essential to prevent vapor accumulation. In case of spills, neutralize with appropriate absorbents and dispose of according to local regulations.
B2B Procurement Guide
When procuring 2-Fluoro-4-bromophenol, prioritize suppliers with a proven track record in fine chemicals. Request detailed documentation including COA, SDS, and batch-specific purity reports (typically 97-99%). Consider packaging options such as amber glass bottles or sealed plastic containers to ensure stability during transport. For bulk purchases, negotiate customized packaging and storage solutions. Verify compliance with relevant regulations (REACH, TSCA) based on your region. Lead times may vary, so plan orders in advance to avoid production delays.
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