Overview
2-Ethoxybenzoic acid is an organic compound primarily used as an intermediate in pharmaceutical manufacturing and organic synthesis. It belongs to the class of aromatic ethers and carboxylic acids, featuring an ethoxy group (-OCH2CH3) and a carboxyl group (-COOH) attached to a benzene ring. The compound is valued for its role in producing active pharmaceutical ingredients (APIs) and specialty chemicals. The synthesis of 2-ethoxybenzoic acid typically involves the ethoxylation of salicylic acid derivatives or other benzoic acid precursors. Its stable crystalline form and moderate solubility in organic solvents make it suitable for various industrial applications.
Physical and Chemical Properties
2-Ethoxybenzoic acid appears as a white to off-white crystalline powder with a molecular weight of 166.17 g/mol. It has a melting point range of 85-88°C and a density of approximately 1.16 g/cm³. The compound is soluble in organic solvents like ethanol and ether but exhibits limited solubility in water. Chemically, it behaves as a weak acid due to the presence of the carboxyl group. The ethoxy group contributes to its lipophilicity, influencing its reactivity and solubility profile. These properties are critical for its performance in synthetic applications and formulation stability.
Main Applications
The primary use of 2-ethoxybenzoic acid is as a building block in pharmaceutical synthesis. It serves as an intermediate in the production of analgesics, anti-inflammatory drugs, and other APIs. Its aromatic and carboxylic functionalities enable versatile chemical transformations. In addition to pharmaceuticals, the compound finds niche applications in agrochemicals and specialty chemicals. It may also be used in research settings for studying reaction mechanisms or developing new synthetic pathways.
Safety and Storage
2-Ethoxybenzoic acid requires careful handling to avoid health risks. Direct contact with skin or eyes can cause irritation, and inhalation of dust should be prevented. Personal protective equipment (PPE) such as gloves, goggles, and lab coats is recommended during handling. Storage conditions should prioritize dryness and cool temperatures, ideally below 25°C, to maintain stability. The compound should be kept in tightly sealed containers away from incompatible substances like strong oxidizers. Proper labeling and hazard communication are essential for workplace safety.
B2B Procurement Guide
When procuring 2-ethoxybenzoic acid, B2B buyers should prioritize suppliers with verified certifications (e.g., ISO, GMP) to ensure quality and regulatory compliance. Key specifications to confirm include purity (typically ≥98%), CAS number (134-11-2), and absence of heavy metals or residual solvents. Pricing varies based on quantity and supplier location, with bulk purchases often yielding cost advantages. Buyers should also evaluate logistics options, as some suppliers offer specialized packaging for hazardous materials. Long-term contracts may provide stability in pricing and supply chain reliability.
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