Overview
2-Cyclohexylpropionic Acid is a carboxylic acid derivative with a cyclohexyl group attached to the propionic acid backbone. It serves as a versatile intermediate in organic synthesis, particularly in pharmaceuticals and agrochemicals. Its molecular structure combines aliphatic and cyclic components, offering unique reactivity for chemical modifications. Industrially, it is produced through catalytic hydrogenation or Grignard reactions, with purity levels typically exceeding 98% for commercial use.
Physical and Chemical Properties
This compound appears as a colorless to pale yellow liquid at room temperature, with a characteristic mild odor. It demonstrates moderate volatility, boiling around 250-260°C, and forms homogeneous solutions with common organic solvents. Chemically, it behaves as a weak acid (pKa ~4.8) and undergoes typical carboxylic acid reactions like esterification and amidation. The cyclohexyl group confers steric hindrance, influencing its reactivity in nucleophilic substitution reactions.
Main Applications
In pharmaceuticals, 2-Cyclohexylpropionic Acid is a key intermediate for non-steroidal anti-inflammatory drugs (NSAIDs) and cholesterol-lowering agents. Its structural features enable targeted molecular modifications during drug development. The agrochemical industry utilizes it in synthesizing herbicides and plant growth regulators. Additionally, it finds niche applications in specialty chemicals, including fragrance ingredients and polymer modifiers.
Safety and Storage
As with most organic acids, proper handling is essential. Use chemical-resistant gloves (nitrile recommended) and eye protection when working with this compound. Ensure adequate ventilation to prevent vapor accumulation. Storage should be in tightly sealed containers, preferably made of HDPE or glass, at temperatures below 30°C. Incompatible with strong oxidizers—maintain separation from such materials. Spills should be contained with inert absorbents and disposed of as hazardous waste.
B2B Procurement Guide
When sourcing 2-Cyclohexylpropionic Acid, prioritize suppliers with ISO 9001 certification and batch-specific Certificates of Analysis (CoA). Technical grade (≥98%) suffices for most industrial applications, while pharmaceutical use may require ≥99.5% purity. Bulk purchases (drum quantities) typically offer 15-30% cost savings compared to small packaging. Consider regional logistics—this chemical is commonly shipped as a UN3265 Class 8 corrosive liquid. Lead times vary from 2-6 weeks depending on supplier inventory.
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