Overview
2-Cyclohexylethylamine is an organic amine compound with a cyclohexyl group attached to an ethylamine backbone. It is primarily used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. The compound is known for its reactivity as a nucleophile and its role in forming amine derivatives. Due to its versatile chemical structure, 2-cyclohexylethylamine is valuable in organic synthesis, particularly in the production of active pharmaceutical ingredients (APIs) and crop protection agents. Its applications extend to corrosion inhibitors and surfactants in industrial processes.
Physical and Chemical Properties
2-Cyclohexylethylamine is a colorless to pale yellow liquid with a distinct amine odor. It has a molecular weight of 127.23 g/mol and a density of approximately 0.86 g/cm³. The compound is hygroscopic, meaning it absorbs moisture from the air, and is soluble in common organic solvents such as ethanol, ether, and acetone. The boiling point ranges between 180-185°C, making it suitable for reactions requiring moderate temperatures. Its reactivity includes forming salts with acids and participating in reductive amination. Proper handling is essential due to its corrosive nature and potential health hazards.
Main Applications
In the pharmaceutical industry, 2-cyclohexylethylamine serves as an intermediate for drugs targeting neurological and cardiovascular conditions. Its cyclohexyl group enhances lipid solubility, improving drug bioavailability. Agrochemical manufacturers use it to synthesize herbicides and fungicides with selective action. The compound also finds use in specialty chemicals, such as surfactants for detergents and emulsifiers in coatings. Its amine functionality allows it to act as a catalyst or modifier in polymer production. Research labs employ it for developing novel compounds with tailored properties.
Safety and Storage
2-Cyclohexylethylamine is corrosive and can cause skin, eye, and respiratory irritation. Always use personal protective equipment (PPE), including nitrile gloves, safety goggles, and fume hoods. Avoid contact with oxidizing agents and strong acids to prevent hazardous reactions. Store the compound in tightly sealed containers under inert gas (e.g., nitrogen) to minimize moisture absorption and oxidation. Keep away from heat sources and open flames. Spills should be neutralized with absorbent materials and disposed of as hazardous waste according to local regulations.
B2B Procurement Guide
When procuring 2-cyclohexylethylamine, prioritize suppliers with certifications like ISO 9001 or GMP. Request a certificate of analysis (CoA) to verify purity (≥98% is typical for industrial use). Bulk purchases (25 kg drums) may offer cost advantages but ensure proper storage capacity. Evaluate lead times and logistics, especially for international shipments, as the compound may require hazardous material documentation. Partner with suppliers providing technical support and SDS (Safety Data Sheets) for compliance with workplace safety standards.
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