Overview
2-Cyanopyrazine is an organic compound belonging to the pyrazine family, characterized by a nitrile group attached to the pyrazine ring. It serves as a versatile intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. The compound's reactivity makes it valuable for constructing complex molecular structures. Due to its role in medicinal chemistry, 2-cyanopyrazine is often utilized in research and industrial applications. Its ability to undergo various chemical transformations allows for the creation of diverse derivatives, enhancing its utility in drug discovery and material science.
Physical and Chemical Properties
2-Cyanopyrazine appears as a white to pale yellow crystalline powder with a molecular weight of 105.10 g/mol. It has a melting point of approximately 90-92°C, though its boiling point is not well-documented. The compound is soluble in common organic solvents such as ethanol and acetone but exhibits limited solubility in water. The nitrile group in 2-cyanopyrazine contributes to its high reactivity, enabling participation in nucleophilic addition and cyclization reactions. This property is particularly valuable in synthetic chemistry, where the compound acts as a building block for more complex molecules.
Main Applications
2-Cyanopyrazine is primarily used as an intermediate in the pharmaceutical industry, where it aids in the synthesis of active pharmaceutical ingredients (APIs). Its derivatives are explored for potential therapeutic applications, including antimicrobial and anticancer agents. In agrochemicals, the compound serves as a precursor for herbicides and pesticides. Additionally, it finds use in organic synthesis for creating heterocyclic compounds, which are essential in material science and specialty chemicals.
Safety and Storage
Handling 2-cyanopyrazine requires precautions due to its potential health hazards. Direct contact with skin or eyes should be avoided, and appropriate personal protective equipment (PPE) such as gloves and goggles must be worn. Inhalation of dust or vapors should be prevented by working in a well-ventilated area or under a fume hood. Storage conditions are critical to maintaining the compound's stability. It should be kept in a cool, dry place, sealed in airtight containers to prevent moisture absorption and degradation. Compatibility with other chemicals should be verified before storage or use.
B2B Procurement Guide
When procuring 2-cyanopyrazine, buyers should prioritize suppliers who provide detailed documentation, including Material Safety Data Sheets (MSDS) and Certificates of Analysis (COA). These documents ensure the product's purity, safety, and compliance with regulatory standards. Pricing varies based on quantity and supplier reputation, with laboratory-scale quantities typically ranging from $50 to $100 per gram. Bulk purchases may offer cost advantages, but quality verification remains essential. Buyers should also assess supplier reliability, lead times, and packaging options to meet their specific needs.
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