Overview
2-Chloropyrazine is a chlorinated derivative of pyrazine, a heterocyclic aromatic compound. It is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals due to its reactive chlorine atom, which allows for further functionalization. The compound is typically synthesized through chlorination of pyrazine using reagents like phosphorus oxychloride. Its versatility in chemical reactions makes it valuable in industrial applications, particularly in the development of active pharmaceutical ingredients (APIs) and crop protection agents.
Physical and Chemical Properties
2-Chloropyrazine is a colorless to pale yellow liquid at room temperature with a distinct odor. It has a molecular weight of 114.53 g/mol and a density of 1.29 g/cm³. The compound is soluble in common organic solvents such as ethanol, ether, and dichloromethane. Its boiling point ranges between 160-162 °C, and it exhibits high reactivity due to the presence of the chlorine atom. The compound is stable under recommended storage conditions but can decompose under extreme heat or in the presence of strong acids or bases.
Main Applications
2-Chloropyrazine is widely used as a building block in the pharmaceutical industry for the synthesis of various drugs, including antiviral and antibacterial agents. Its reactivity allows for the introduction of other functional groups, making it a versatile intermediate. In the agrochemical sector, it is employed in the production of herbicides and pesticides. The compound's ability to act as a precursor for more complex molecules makes it indispensable in research and industrial chemistry.
Safety and Storage
2-Chloropyrazine is classified as corrosive and harmful if swallowed or inhaled. Proper personal protective equipment (PPE), including gloves, goggles, and lab coats, should be worn when handling the compound. Adequate ventilation is essential to avoid inhalation of vapors. The compound should be stored in a cool, dry place away from light and moisture. Containers must be tightly sealed to prevent contamination and degradation. Spills should be neutralized with appropriate absorbents and disposed of in accordance with local regulations.
B2B Procurement Guide
When procuring 2-Chloropyrazine, it is crucial to verify the supplier's credentials and ensure they provide a Material Safety Data Sheet (MSDS) and certificates of analysis (CoA) to confirm purity and quality. Bulk purchases may offer cost advantages, but storage capacity and shelf life should be considered. Prices typically range between $50-$100 per kg, depending on quantity and supplier. It is advisable to request samples for quality testing before large-scale procurement. Long-term contracts with reliable suppliers can ensure consistent quality and supply chain stability.
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