2-Chlorobenzoylacetonitrile

Updated: 2026-08-28

Overview

2-Chlorobenzoylacetonitrile is an organic compound with the molecular formula C9H6ClNO. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound features a reactive nitrile group and a chlorobenzoyl moiety, making it versatile for various chemical reactions. Its primary role in industrial applications is as a building block for more complex molecules. Due to its reactivity, it is often handled under controlled conditions to ensure safety and efficacy in synthesis processes.

Physical and Chemical Properties

2-Chlorobenzoylacetonitrile appears as a white to pale yellow crystalline powder. It has a melting point of approximately 60-65°C and is soluble in common organic solvents like ethanol and acetone, though it is only slightly soluble in water. The compound's molecular weight is 179.60 g/mol, and its structure includes a nitrile group that is highly reactive, making it useful for further chemical modifications. Its stability under normal conditions makes it suitable for storage and transportation in industrial settings.

Main Applications

The primary use of 2-Chlorobenzoylacetonitrile is in the pharmaceutical industry, where it serves as an intermediate for the synthesis of active pharmaceutical ingredients (APIs). It is also employed in agrochemical production, particularly in the creation of pesticides and herbicides. Additionally, its reactive properties make it valuable in organic synthesis for constructing more complex molecular frameworks. Researchers and manufacturers favor it for its consistent performance and relatively straightforward handling requirements.

Safety and Storage

2-Chlorobenzoylacetonitrile is classified as harmful if swallowed or inhaled, and it can cause skin and eye irritation. Proper personal protective equipment (PPE), including gloves and goggles, should be worn when handling this chemical. Storage recommendations include keeping the compound in a cool, dry place away from direct light and moisture. Containers should be tightly sealed to prevent contamination and degradation. In case of spillage, absorb with inert material and dispose of according to local regulations.

B2B Procurement Guide

When procuring 2-Chlorobenzoylacetonitrile, buyers should verify the CAS number (4473-82-1) and purity specifications to ensure product quality. It is advisable to request certificates of analysis (CoA) from suppliers. Bulk purchases often come with discounts, so buyers should inquire about volume-based pricing. Reliable suppliers typically offer technical support and detailed safety data sheets (SDS). Comparing multiple suppliers for lead times and logistical support can optimize procurement efficiency.