Overview
2'-Chloroacetophenone is an organic compound widely used as an intermediate in chemical synthesis. It is a colorless to pale yellow liquid with a distinct aromatic odor. The compound is primarily utilized in the pharmaceutical and fragrance industries due to its reactivity and versatility in organic reactions. Its molecular structure consists of a phenyl group attached to a chloro-substituted acetyl group, making it a valuable building block for more complex molecules. The compound is typically synthesized through Friedel-Crafts acylation of benzene derivatives.
Physical and Chemical Properties
2'-Chloroacetophenone has a molecular weight of 154.59 g/mol and a density of 1.188 g/cm³. It is a flammable liquid with a boiling point of approximately 244°C and a melting point around -10°C. The compound is soluble in common organic solvents such as ethanol, ether, and acetone but has limited solubility in water. Its chemical reactivity is characterized by the presence of a reactive carbonyl group and a chlorine substituent, which makes it useful for nucleophilic substitution reactions. The compound should be handled with care due to its irritant properties and potential to cause skin and eye damage.
Main Applications
2'-Chloroacetophenone serves as a key intermediate in the synthesis of pharmaceuticals, including antihistamines and anti-inflammatory drugs. It is also used in the production of fragrances and flavors, where its aromatic properties are leveraged to create complex scent profiles. In addition, the compound finds applications in agrochemicals and specialty chemicals. Its reactivity allows it to be transformed into various derivatives, making it a versatile component in organic synthesis laboratories and industrial settings.
Safety and Storage
Due to its flammable nature and irritant properties, 2'-Chloroacetophenone requires careful handling. It should be stored in a cool, dry place away from direct sunlight and oxidizing agents. Containers must be tightly sealed to prevent evaporation and contamination. Personal protective equipment (PPE), such as gloves and safety goggles, should be worn when handling the compound. In case of spillage, absorbent materials like sand or vermiculite should be used, and the area should be ventilated. Proper disposal methods must be followed to minimize environmental impact.
B2B Procurement Guide
When procuring 2'-Chloroacetophenone, it is essential to verify the supplier's credentials and request a Certificate of Analysis (CoA) to ensure product purity. Buyers should also review the Safety Data Sheet (SDS) for handling and storage guidelines. Prices vary based on purity levels and order quantities, typically ranging from $50 to $100 per kilogram. Bulk purchases may qualify for discounts. It is advisable to establish long-term relationships with reputable suppliers to ensure consistent quality and reliable delivery schedules.
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