2-Chloro-5-nitrobenzaldehyde
Overview
2-Chloro-5-nitrobenzaldehyde is a nitro-substituted aromatic aldehyde with the molecular formula C7H4ClNO3. It is widely used as a building block in organic synthesis, particularly in pharmaceuticals and agrochemicals. The compound is characterized by its yellow crystalline appearance and reactivity due to the presence of both aldehyde and nitro functional groups. Its primary role is as an intermediate in the synthesis of more complex molecules.
Physical and Chemical Properties
2-Chloro-5-nitrobenzaldehyde is a stable compound under normal conditions but may decompose under extreme heat or prolonged exposure to light. It has a melting point of approximately 80-82°C and is soluble in common organic solvents like ethanol and acetone. The presence of both electron-withdrawing groups (chloro and nitro) makes the aldehyde group highly reactive, facilitating its use in nucleophilic addition reactions. Its molecular weight is 185.56 g/mol, and it typically appears as a yellow crystalline powder.
Main Applications
This compound is primarily utilized as an intermediate in the pharmaceutical industry, where it serves as a precursor for drugs and active pharmaceutical ingredients (APIs). It is also used in agrochemical synthesis for producing herbicides and pesticides. Additionally, 2-Chloro-5-nitrobenzaldehyde finds applications in dye manufacturing, where its nitro group contributes to color development. Its reactivity makes it valuable in research and specialty chemical production for creating custom derivatives.
Safety and Storage
2-Chloro-5-nitrobenzaldehyde should be handled with care due to its potential to irritate skin and eyes. Proper personal protective equipment (PPE), including gloves and goggles, is recommended during use. Storage should be in a cool, dry place, away from direct sunlight and moisture. The compound is stable under normal conditions but may degrade if exposed to extreme temperatures or incompatible substances. Always refer to the material safety data sheet (MSDS) for detailed handling instructions.
B2B Procurement Guide
When procuring 2-Chloro-5-nitrobenzaldehyde, prioritize suppliers who provide certificates of analysis (CoA) to verify purity (typically ≥98%). Confirm the CAS number (6628-85-7) to ensure product authenticity. Bulk buyers should inquire about customization options, such as particle size or packaging preferences. Prices commonly range between $50-$150 per kg, depending on quantity and supplier. Establish long-term contracts with reliable manufacturers to ensure consistent quality and supply chain stability.
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