2-Chloro-4-aminopyridine hydrochloride

Updated: 2026-07-21

Overview

2-Chloro-4-aminopyridine Hydrochloride is an important organic compound primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its molecular structure features a pyridine ring substituted with chlorine and amino groups, making it a versatile building block in organic chemistry. The compound is widely recognized for its role in the production of active pharmaceutical ingredients (APIs) and crop protection agents. Its stability and reactivity under controlled conditions make it a preferred choice for industrial applications.

Physical and Chemical Properties

2-Chloro-4-aminopyridine Hydrochloride appears as a white to off-white crystalline powder. It is hygroscopic, meaning it absorbs moisture from the air, which necessitates proper storage conditions to maintain its integrity. The compound decomposes at temperatures around 220-225°C, and it is soluble in water and common polar organic solvents like methanol and ethanol. Its molecular weight is 179.03 g/mol, and it exhibits typical amine and pyridine reactivity. The presence of both chlorine and amino groups on the pyridine ring allows for diverse chemical transformations, making it valuable in synthetic chemistry.

Main Applications

The primary use of 2-Chloro-4-aminopyridine Hydrochloride is as an intermediate in the pharmaceutical industry. It is employed in the synthesis of various drugs, including antiviral and antibacterial agents. Its role in creating complex molecules stems from its ability to undergo nucleophilic substitution and other reactions. In agrochemicals, this compound is used to develop pesticides and herbicides. Its structural features contribute to the efficacy of these products by enhancing their interaction with biological targets. Additionally, it finds niche applications in research and specialty chemical synthesis.

Safety and Storage

Handling 2-Chloro-4-aminopyridine Hydrochloride requires caution due to its potential health hazards. Direct contact with skin or eyes can cause irritation, and inhalation of dust should be avoided. Proper personal protective equipment (PPE), such as gloves and goggles, is essential when working with this compound. Storage conditions are critical to maintaining its stability. The compound should be kept in a tightly sealed container in a cool, dry place, away from light and moisture. Prolonged exposure to humid environments can lead to degradation, reducing its effectiveness in applications.

B2B Procurement Guide

When procuring 2-Chloro-4-aminopyridine Hydrochloride, B2B buyers should prioritize suppliers with a proven track record of quality and reliability. Key factors to consider include the compound's purity (typically 98% or higher), packaging integrity, and compliance with regional regulatory standards. Price negotiations should account for order volume, with bulk purchases often attracting discounts. It is advisable to request certificates of analysis (CoA) and material safety data sheets (MSDS) to ensure the product meets specifications. Additionally, buyers should assess logistics options to guarantee timely and safe delivery.