Overview
2-Bromothiazole is a brominated derivative of thiazole, a sulfur- and nitrogen-containing heterocycle. It serves as a versatile intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its reactive bromine atom enables cross-coupling reactions, making it valuable for constructing complex molecules. First synthesized in the mid-20th century, 2-bromothiazole is now commercially available from specialty chemical suppliers. It is typically shipped as a neat liquid or in solution, with strict handling requirements due to its corrosive nature.
Physical and Chemical Properties
As a liquid at room temperature, 2-bromothiazole has a density higher than water (1.75 g/cm³) and boils at 170-172°C. It is sparingly soluble in water but miscible with common organic solvents like ethanol, diethyl ether, and dichloromethane. The compound’s reactivity stems from the bromine atom at the 2-position, which participates readily in nucleophilic substitution and metal-catalyzed coupling reactions (e.g., Suzuki, Stille). The thiazole ring also contributes to its stability under acidic conditions, unlike some other heterocyclic bromides.
Main Applications
In pharmaceuticals, 2-bromothiazole is a key intermediate for antibiotics, antivirals, and kinase inhibitors. For example, it is used in the synthesis of thiazole-containing drugs like tiazofurin. Agrochemical manufacturers employ it to produce fungicides and herbicides with thiazole moieties. Beyond life sciences, it finds niche use in materials science for synthesizing conductive polymers and ligands for catalysis. Its ability to act as a precursor for thiazole-based fluorescent dyes is also under research.
Safety and Storage
2-Bromothiazole is corrosive and can cause severe burns upon contact with skin or eyes. Always use nitrile gloves, goggles, and a lab coat when handling. Work in a fume hood to avoid inhalation of vapors, which may irritate the respiratory tract. Store in amber glass bottles or sealed drums under inert gas (e.g., nitrogen) to prevent degradation. Keep away from oxidizers and strong bases. Shelf life is typically 1-2 years when stored at 2-8°C.
B2B Procurement Guide
When sourcing 2-bromothiazole, prioritize suppliers with analytical certificates (CoA) specifying purity (≥98%) and impurity profiles. Bulk buyers should negotiate discounts for drum quantities (25-200 kg), while small-scale users may opt for ampoules (5-50 g). Logistics require hazardous chemical shipping compliance (UN/ADR). Confirm supplier adherence to REACH or TSCA regulations if importing. Lead times vary; specialty orders may take 4-8 weeks. Alternatives like 2-chlorothiazole exist but differ in reactivity.
Related Manufacturers
- 主营：溴噻唑、精细化工品、有机中间体
- 主营：增塑剂、草酸镍、阻燃剂、1-二十烯、栀子蓝、抗氧剂、偶联剂、异壬酸、间氟溴苄、异胞嘧啶、磷酸三钾、油墨油剂、洗涤助剂、苯磺酸钠、单体香料、环磺酮酸、分散染料、无机颜料、苹果酸镁、表面处理剂、丙二醇甲醚、化妆品原料、丁酸甘油酯、硅烷处理剂、表面活性剂
- 主营：甜菊糖、氯乙酰、二乙苯、4316-73-8、4861-19-2、1192-62-7、7783-40-6、8002-74-2、7782-61-8、2842-44-6、1310-58-3、酞菁绿、阻燃剂、二戊烯、单甲醚、硫酸锂、大理石、羊脂酸、磷酸氢、龙脑油、聚甘油、二聚酸、戊二醇、聚醚f68、磺化油
- 主营：二甲基亚砜、乙二醇、丙二醇、溴噻唑氢溴酸盐、DMAC
- 主营：全氟三丁胺、二苄叉山梨醇、六氟丙烯二聚体、溴噻唑、六氟环氧丙烷二聚体、异丙醇铝、纳米勃姆石、二异戊基硫醚、隐色结晶紫、邻菲罗啉
- 主营：化学品、香精香料、试剂、溴噻唑、中间体、有机硅、橡胶树脂、催化剂、纳米材料
- 主营：三硫代碳酸钠、聚乙烯亚胺、三乙二醇二异辛酸酯、红色素-16、L-丙交酯、石油酯-T50、巯基苯并噻唑钠、乙交酯、多元醇苯甲酸酯、热压敏染料、光稳定剂、高分子降解材料
- 主营：有机原料、中间体、香精香料、催化剂、有机硅、表面活性剂
- 主营：香精、食用香料
- 主营：异丙醇、二甲胺、二甲苯、溴噻唑、苯基氯、二甘醇、石炭酸、乙二醇、丙烯酸、仲丁醇、水溶液、羟基苯、红铅丹、氨基苯、安息油、环己醇、正丁醇、84消毒液、单乙醇胺、医用酒精、液状石蜡、邻甲苯胺、杀菌消毒、乙基三胺、出口酒精、乙烯基苯
- 主营：全氟聚醚二醇、全氟三丁胺、聚硅氮烷、溴噻唑、特种硅油、特种硅树脂
- 主营：2-十一酮、乙酸龙脑酯、聚苯乙烯磺酸钠、乙基黄原酸钾
- 主营：环戊酮、甲酸镍、阻燃剂、溴噻唑、草酸镧、钼酸铵、催化剂、钒酸铋、溴氨酸、硝酸锆、碳酸镧、白僵菌、磷酸铁、钨酸酐、氟化镧、视黄醇、叔丁醇、杀螨剂、杀虫剂、醋酸钬、抗粘剂、氟化镥、肟菌酯、氢化钠、氯铂酸、氟化镁
- 主营：硼酸酐、阻聚剂、己二酸、6-氯嘌呤、氯化锂、发泡剂、乙二醇、醋酸铜、硅酸钠、正癸醇、新癸酸、环烷油、腰果酚、十二醇、酒石酸、碳酸锂、三甘醇、油菜酸、二甘醇、碳酸钾、甲酸钠、硅酸镁、棕榈油、微晶石蜡、磷酸一铵
- 主营：扩链剂、咪唑系列、阻燃剂、溴噻唑、离子液体、催化剂、乙酰丙酮系列、固化剂系列