Overview
2-Amino-4-chloro-3-pyridinecarboxylic acid is an organic compound primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its molecular structure features a pyridine ring substituted with amino, chloro, and carboxylic acid functional groups, making it a versatile building block in organic chemistry. This compound is particularly valued for its role in the production of active pharmaceutical ingredients (APIs) and crop protection agents. Its controlled synthesis and purity are critical for ensuring the efficacy and safety of the final products in which it is incorporated.
Physical and Chemical Properties
2-Amino-4-chloro-3-pyridinecarboxylic acid typically appears as an off-white to light yellow crystalline powder. It has a molecular weight of 172.57 g/mol and decomposes at temperatures around 200-210°C. The compound is sparingly soluble in water but exhibits better solubility in polar organic solvents such as ethanol and dimethyl sulfoxide (DMSO). Its chemical stability under normal conditions makes it suitable for various synthetic applications, though it may degrade when exposed to strong oxidizing agents. The presence of both amino and carboxylic acid groups allows for further functionalization, making it a valuable intermediate in multi-step synthesis processes.
Main Applications
The primary application of 2-amino-4-chloro-3-pyridinecarboxylic acid is as a key intermediate in the pharmaceutical industry. It is used in the synthesis of various drugs, including those targeting central nervous system disorders and infectious diseases. The compound's structural features enable the introduction of additional functional groups, facilitating the creation of complex molecules. In agrochemicals, this intermediate is employed in the production of pesticides and herbicides. Its derivatives often exhibit bioactivity, making them effective in protecting crops from pests and diseases. The demand for high-purity grades of this compound is driven by stringent regulatory requirements in both pharmaceutical and agricultural sectors.
Safety and Storage
Proper handling of 2-amino-4-chloro-3-pyridinecarboxylic acid is essential to ensure workplace safety. The compound should be stored in a cool, dry environment, protected from light and moisture to prevent degradation. Containers must be tightly sealed to avoid contamination and exposure to air. Personal protective equipment (PPE), including gloves, goggles, and lab coats, should be worn when handling this chemical. In case of skin contact, immediate washing with soap and water is recommended. Inhalation or ingestion requires prompt medical attention. Safety data sheets (SDS) provided by suppliers should be consulted for detailed emergency procedures.
B2B Procurement Guide
When procuring 2-amino-4-chloro-3-pyridinecarboxylic acid, B2B buyers should prioritize suppliers with a proven track record of quality and reliability. Key factors to consider include the compound's purity (typically 98% or higher), batch-to-batch consistency, and compliance with relevant industry standards. It is advisable to request certificates of analysis (CoA) and ensure that the supplier can provide adequate documentation for traceability. Pricing can vary significantly based on quantity, purity, and supplier location, with bulk purchases often attracting discounts. Buyers should also evaluate logistics options to ensure safe and timely delivery, especially for international transactions.
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