2-Amino-3-bromo-5-nitropyridine

Updated: 2026-07-31

Overview

2-Amino-3-bromo-5-nitropyridine is a heterocyclic organic compound primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its molecular structure includes amino, bromo, and nitro functional groups, making it a versatile building block for more complex molecules. The compound is typically supplied as a yellow to brown crystalline powder and requires careful handling due to its reactive nature. This compound is particularly valuable in medicinal chemistry, where it serves as a precursor for drugs targeting various diseases. Its synthesis involves multi-step organic reactions, often requiring specialized equipment and expertise. B2B buyers should verify the purity and analytical data provided by suppliers to ensure suitability for their intended applications.

Physical and Chemical Properties

2-Amino-3-bromo-5-nitropyridine has a molecular weight of 218.01 g/mol and appears as a yellow to brown crystalline powder. It is slightly soluble in water but dissolves more readily in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). The exact melting and boiling points are not widely documented, but it is known to decompose at elevated temperatures. The presence of both electron-withdrawing (nitro) and electron-donating (amino) groups on the pyridine ring creates unique reactivity patterns. This makes the compound useful for nucleophilic substitution reactions and other transformations in synthetic chemistry. Stability under various conditions should be confirmed with the supplier, as impurities or improper storage can affect performance.

Main Applications

The primary use of 2-amino-3-bromo-5-nitropyridine is as an intermediate in the pharmaceutical industry. It is employed in the synthesis of active pharmaceutical ingredients (APIs) for drugs targeting infections, cancer, and neurological disorders. The bromo and nitro groups allow for further functionalization, enabling the creation of diverse molecular architectures. In agrochemicals, this compound contributes to the development of pesticides and herbicides. Its reactivity facilitates the construction of heterocyclic scaffolds that are common in crop protection agents. Researchers also explore its potential in material science, particularly in the design of organic semiconductors and ligands for catalytic systems.

Safety and Storage

2-Amino-3-bromo-5-nitropyridine should be handled with appropriate personal protective equipment (PPE), including gloves, lab coats, and safety goggles. Avoid inhalation of dust and prevent skin or eye contact, as it may cause irritation or sensitization. Work should be conducted in a well-ventilated area or under a fume hood to minimize exposure. Storage conditions are critical to maintaining the compound's stability. It should be kept in a tightly sealed container in a cool, dry place, away from light and moisture. Incompatible materials include strong oxidizing agents and acids. Suppliers typically provide Safety Data Sheets (SDS) with detailed hazard and first-aid information, which should be reviewed before use.

B2B Procurement Guide

When procuring 2-amino-3-bromo-5-nitropyridine, B2B buyers should prioritize suppliers with a proven track record in fine chemical manufacturing. Key factors to evaluate include purity (typically 97% or higher), batch-to-batch consistency, and comprehensive analytical documentation (e.g., HPLC, NMR data). Pricing varies based on quantity and purity, with bulk orders generally offering cost advantages. Lead times can be significant due to the specialized nature of production, so advance planning is advisable. Buyers should also confirm regulatory compliance, such as REACH registration, if applicable. For international shipments, proper packaging and hazardous material labeling are essential to ensure safe transportation. Establishing long-term partnerships with reliable suppliers can mitigate supply chain risks.