Overview
2'-Acetonaphthone, also known as β-Naphthyl ethyl ketone, is an aromatic ketone derived from naphthalene. It is primarily synthesized through Friedel-Crafts acylation of naphthalene. The compound is valued for its role as a versatile intermediate in organic synthesis. Industrially, it is produced under controlled conditions to ensure high purity, typically ≥98%. Its crystalline form and distinct aromatic properties make it suitable for applications in pharmaceuticals, perfumery, and specialty chemicals.
Physical and Chemical Properties
2'-Acetonaphthone appears as a white to pale yellow crystalline solid with a characteristic aromatic odor. It has a melting point of 52-54°C and a boiling point of 300-302°C. The compound is soluble in common organic solvents like ethanol and ether but exhibits negligible solubility in water. Its stability under standard conditions and compatibility with various reagents make it a reliable building block in synthetic chemistry. The density of 1.12 g/cm³ and molecular weight of 170.21 g/mol are key identifiers for quality control.
Main Applications
In the pharmaceutical industry, 2'-Acetonaphthone serves as an intermediate for synthesizing active pharmaceutical ingredients (APIs), particularly in antihistamines and anti-inflammatory drugs. Its aromatic profile also makes it a component in high-end fragrances and flavor enhancers. The dye industry utilizes this compound to produce naphthol-based dyes, which are known for their vivid colors and lightfastness. Additionally, it is employed in research laboratories for studying ketone reactions and developing novel organic compounds.
Safety and Storage
Handling 2'-Acetonaphthone requires precautions due to its potential irritant effects. Direct contact with skin or eyes should be avoided, and adequate ventilation is necessary to prevent inhalation of dust or vapors. PPE such as gloves and safety goggles is recommended. Storage should be in tightly sealed containers, away from heat sources and oxidizing agents. The compound is stable under normal temperatures but may degrade if exposed to moisture or extreme conditions. Spills should be contained using inert absorbents and disposed of according to local regulations.
B2B Procurement Guide
When procuring 2'-Acetonaphthone, prioritize suppliers with ISO or GMP certifications to ensure product consistency and traceability. Key specifications to verify include purity (≥98%), residual solvent levels, and absence of heavy metals. Bulk pricing is typically negotiable, with discounts available for orders exceeding 100 kg. Lead times may vary depending on supplier inventory, so advance planning is advised. Request samples for quality testing before large-scale purchases, and confirm logistics options for safe transportation.
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