Overview
2-(4-Fluorophenyl)pyridine is an organic compound belonging to the class of aromatic heterocycles. It features a pyridine ring substituted with a 4-fluorophenyl group at the 2-position. This structure makes it a valuable intermediate in the synthesis of more complex molecules, particularly in pharmaceuticals and agrochemicals. Its synthesis typically involves cross-coupling reactions, such as Suzuki-Miyaura coupling, which allows for the introduction of the fluorophenyl group onto the pyridine ring. The compound's stability and reactivity make it a versatile building block in organic chemistry.
Physical and Chemical Properties
2-(4-Fluorophenyl)pyridine is a white to light yellow crystalline powder at room temperature. It is soluble in common organic solvents like ethanol, methanol, and acetone but has limited solubility in water. The presence of the fluorine atom enhances its stability and influences its electronic properties, making it useful in various chemical reactions. The compound's molecular weight is 173.19 g/mol, and its exact melting and boiling points are not widely documented. However, it is known to be stable under normal storage conditions, provided it is kept away from moisture and direct sunlight.
Main Applications
The primary use of 2-(4-Fluorophenyl)pyridine is as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its structure allows for further functionalization, enabling the creation of complex molecules with specific biological activities. In the pharmaceutical industry, it is often employed in the development of drugs targeting central nervous system disorders, cancer, and other medical conditions. In agrochemicals, it serves as a precursor for pesticides and herbicides, contributing to crop protection and yield improvement.
Safety and Storage
Handling 2-(4-Fluorophenyl)pyridine requires caution due to its potential health hazards. It is advisable to use personal protective equipment (PPE), including gloves, goggles, and lab coats, to prevent skin contact, inhalation, or ingestion. Storage should be in a cool, dry place, away from direct sunlight and moisture. The compound should be kept in a tightly sealed container to prevent degradation. Proper labeling and adherence to safety protocols are essential to ensure safe handling and storage.
B2B Procurement Guide
When procuring 2-(4-Fluorophenyl)pyridine, it is crucial to verify the supplier's reliability and the product's purity. Requesting safety data sheets (SDS) and certificates of analysis (CoA) can help ensure the compound meets the required specifications. The reference price range is approximately $50-$200 per gram, depending on purity and supplier. Bulk purchases may offer cost advantages, but buyers should balance price considerations with quality assurance. Establishing long-term relationships with reputable suppliers can also enhance procurement efficiency.
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