Overview
2-(2-Hydroxyethyl)pyridine is an organic compound featuring both a pyridine ring and a hydroxyethyl functional group. This dual functionality makes it a valuable intermediate in chemical synthesis. It is commercially produced through the reaction of pyridine with ethylene oxide under controlled conditions. The compound is particularly significant in the pharmaceutical industry, where it serves as a building block for various active pharmaceutical ingredients (APIs). Its versatility also extends to agrochemical applications, where it is used in the synthesis of herbicides and fungicides.
Physical and Chemical Properties
2-(2-Hydroxyethyl)pyridine is a colorless to pale yellow liquid with a characteristic pyridine-like odor. It has a density of 1.07 g/cm³ and a boiling point between 250-252°C. The compound is hygroscopic, meaning it readily absorbs moisture from the air, which necessitates proper storage conditions. Chemically, it acts as a weak base due to the pyridine nitrogen and exhibits reactivity through its hydroxyl group. This allows for various derivatization reactions, making it a versatile intermediate in organic synthesis. It is soluble in water and most common organic solvents, enhancing its utility in different chemical processes.
Main Applications
The primary use of 2-(2-Hydroxyethyl)pyridine is as an intermediate in the pharmaceutical industry. It is a key precursor in the synthesis of drugs targeting the central nervous system and cardiovascular diseases. Its ability to form stable complexes also makes it useful in corrosion inhibitors for industrial applications. In agrochemicals, the compound is employed in the production of herbicides and plant growth regulators. Additionally, it finds niche applications in the manufacture of specialty chemicals, including dyes, fragrances, and polymer additives. Its reactivity and solubility profile make it a preferred choice for these diverse applications.
Safety and Storage
2-(2-Hydroxyethyl)pyridine is classified as an irritant, capable of causing skin and eye irritation upon contact. Proper personal protective equipment (PPE), including gloves and safety goggles, should always be worn when handling this chemical. Work should be conducted in a well-ventilated area or under a fume hood to avoid inhalation exposure. Storage requires attention to its hygroscopic nature. The compound should be kept in tightly sealed containers, preferably made of stainless steel or glass, and stored in a cool, dry place away from direct sunlight and heat sources. Compatibility with other chemicals should be verified to prevent hazardous reactions.
B2B Procurement Guide
When procuring 2-(2-Hydroxyethyl)pyridine, B2B buyers should prioritize suppliers with proven track records in chemical manufacturing. Key considerations include verifying the compound's purity (typically 98-99%), which can significantly impact its performance in downstream applications. Packaging options range from small laboratory-scale bottles to large industrial drums or intermediate bulk containers (IBCs). Certifications such as ISO 9001 or GMP compliance are indicators of a supplier's reliability. Buyers should also request material safety data sheets (MSDS) and certificates of analysis (CoA) to ensure regulatory compliance. Price negotiations should account for bulk purchase discounts and logistics costs, especially for international shipments.
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