Overview
1β-Hydroxyalantolactone Standard is a certified reference material derived from elecampane (Inula helenium), a medicinal plant in the Asteraceae family. As a sesquiterpene lactone compound, it serves as a crucial analytical standard in pharmaceutical quality control and natural product research. The standard is produced under strict quality protocols to ensure batch-to-batch consistency, with typical purity levels exceeding 98% as verified by HPLC. In B2B transactions, this standard is primarily supplied to pharmaceutical companies, research institutions, and contract testing laboratories. Its molecular structure contains a characteristic α-methylene-γ-lactone moiety, which is responsible for many of its bioactive properties. The compound is particularly valued for standardizing herbal preparations and validating analytical methods for sesquiterpene lactone quantification.
Physical and Chemical Properties
1β-Hydroxyalantolactone presents as a white crystalline solid with a melting point range of 140-143°C. The compound shows moderate solubility in organic solvents like DMSO and methanol, but limited solubility in water. Its molecular structure features a five-membered lactone ring and three cyclohexane rings, contributing to its stability under proper storage conditions. Chromatographically, the standard exhibits characteristic UV absorption at 210-220 nm, making it suitable for HPLC analysis with UV detection. The compound demonstrates good stability when stored refrigerated in amber vials, though prolonged exposure to heat, light, or moisture should be avoided. Mass spectrometry typically shows a molecular ion peak at m/z 248 corresponding to its molecular weight.
Main Applications
The primary application of 1β-Hydroxyalantolactone Standard is as a reference material for quality control in herbal medicine production, particularly for elecampane-derived products. Analytical laboratories use it to develop and validate HPLC, LC-MS, and TLC methods for sesquiterpene lactone quantification. In pharmaceutical research, it serves as a standard for pharmacokinetic studies and metabolite identification. The compound is also employed as a bioactive marker in studies investigating anti-inflammatory and anticancer properties of natural products. Research institutions utilize it in structure-activity relationship studies of sesquiterpene lactones. Additionally, nutraceutical companies may use the standard to standardize botanical extracts containing this bioactive compound.
Safety and Storage
As a reference standard, 1β-Hydroxyalantolactone should be handled with appropriate laboratory precautions. The compound may cause skin and eye irritation, necessitating the use of gloves, protective eyewear, and proper ventilation. It is not intended for human or animal consumption and should only be used by trained professionals in controlled settings. For long-term stability, the material should be stored in tightly sealed containers at 2-8°C, protected from light and moisture. Under these conditions, the standard typically maintains its certified purity for at least 24 months. For laboratory use, working solutions should be prepared fresh when possible, and any remaining solutions should be stored at -20°C for short-term use.
B2B Procurement Guide
When procuring 1β-Hydroxyalantolactone Standard, B2B buyers should prioritize suppliers that provide comprehensive certificates of analysis (COA) including HPLC chromatograms, mass spectra, and residual solvent data. The COA should clearly state the purity level (typically ≥98%) and batch-specific information. Reputable suppliers often offer analytical standards that comply with pharmacopeial requirements. Consider requesting a small test quantity before large purchases to verify product quality. Shipping conditions are critical - the standard should be transported with cold packs and proper insulation. For international shipments, verify that the supplier has experience with customs documentation for reference materials. Bulk purchases may be available at discounted rates for certified research institutions or pharmaceutical manufacturers.
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