Overview
17-Isoallopregnanolone is a naturally occurring neurosteroid and a metabolite of progesterone. It is structurally related to allopregnanolone and exhibits similar activity as a positive allosteric modulator of GABA-A receptors. This compound has gained attention in neuroscience research due to its potential role in modulating brain function and its possible therapeutic applications in neurological and psychiatric disorders. As a neuroactive steroid, 17-isoallopregnanolone influences neuronal excitability and has been studied for its effects on mood, cognition, and stress response. While not as extensively researched as some other neurosteroids, it represents an important compound in understanding the complex interactions between steroid hormones and the central nervous system.
Physical and Chemical Properties
17-Isoallopregnanolone is a steroid compound with the molecular formula C21H34O2 and a molecular weight of 318.5 g/mol. It typically appears as a white to off-white crystalline powder at room temperature. The compound is lipophilic and shows good solubility in organic solvents such as ethanol, methanol, and dimethyl sulfoxide, but has limited solubility in water. The exact melting point and boiling point of 17-isoallopregnanolone are not well-documented in literature. Its chemical structure features the characteristic four-ring steroid backbone with hydroxyl and ketone functional groups that contribute to its biological activity. The compound is stable under normal storage conditions but should be protected from prolonged exposure to light and moisture.
Main Applications
The primary application of 17-isoallopregnanolone is in neuroscience research, where it serves as a valuable tool for studying neurosteroid function and GABAergic neurotransmission. Researchers investigate its effects on neuronal excitability, stress response, and potential therapeutic benefits for conditions such as anxiety, depression, and epilepsy. In pharmaceutical development, 17-isoallopregnanolone and related neurosteroids are being explored as potential treatments for various central nervous system disorders. While clinical applications are still in investigational stages, the compound's ability to modulate GABA receptors makes it a candidate for developing novel psychotropic medications with potentially fewer side effects than conventional drugs.
Safety and Storage
17-Isoallopregnanolone should be handled with appropriate laboratory precautions. While specific toxicity data may be limited for this particular compound, as with all neurosteroids, it should be treated as potentially bioactive material. Avoid inhalation of dust and prevent skin contact by using appropriate personal protective equipment including gloves and lab coats. For long-term storage, the compound should be kept in a tightly sealed container under inert atmosphere at temperatures between 2-8°C. Protect from light and moisture to maintain stability. Proper labeling and secure storage are essential, especially in research settings where controlled substances regulations may apply.
B2B Procurement Guide
When procuring 17-isoallopregnanolone for research or development purposes, buyers should prioritize suppliers that provide comprehensive analytical documentation, including certificates of analysis (COA) detailing purity, identity confirmation, and potential impurities. Reputable suppliers should be able to provide information about the synthetic route and quality control procedures. Consider ordering small test quantities initially to verify product quality before committing to larger purchases. Pricing varies significantly based on purity grade (typically 95-99% for research purposes) and order volume. Lead times may be longer than for more common chemicals due to the specialized nature of neurosteroid synthesis. Ensure compliance with all applicable regulations for international shipping if sourcing from overseas suppliers.
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