Overview
1,6-Hexanedithiol is an aliphatic dithiol compound characterized by two reactive thiol (-SH) groups at the terminal positions of a hexane chain. It serves as a versatile intermediate in organic synthesis and material science due to its ability to form disulfide bonds or bind to metal surfaces. The compound is particularly valued in industries requiring controlled crosslinking or surface functionalization. First synthesized in the mid-20th century, it gained prominence in polymer chemistry for creating elastomers with enhanced mechanical properties. Its bifunctional nature allows it to act as a bridge between molecules, making it indispensable in nanotechnology for self-assembled monolayers (SAMs).
Physical and Chemical Properties
As a liquid at room temperature, 1,6-hexanedithiol exhibits a density close to water (∼1.0 g/cm³) and a boiling point of 220–225°C. The thiol groups impart a strong, unpleasant odor typical of mercaptans. Its solubility profile favors organic solvents like ethanol and acetone, while it remains immiscible with water. The compound’s reactivity is dominated by the thiol groups, which readily oxidize to disulfides or form complexes with metals like gold and silver. This property is exploited in surface coating applications. Storage requires inert atmospheres (nitrogen/argon) to prevent oxidation, and containers should be amber glass or metal to limit light exposure.
Main Applications
In polymer science, 1,6-hexanedithiol is a critical crosslinking agent for polyurethanes and rubbers, improving tensile strength and thermal stability. It also serves as a chain extender in epoxy resins. The electronics industry utilizes it to functionalize gold surfaces in sensor fabrication, leveraging its affinity for metal substrates. Nanotechnology applications include creating SAMs on nanoparticles for drug delivery systems. Additionally, it acts as a corrosion inhibitor in lubricants and as a modifier in adhesive formulations to enhance bonding durability. Emerging uses span quantum dot stabilization and conductive ink production.
Safety and Storage
Due to its corrosive nature and volatile thiol groups, 1,6-hexanedithiol requires strict handling protocols. PPE (gloves, goggles, respirators) is mandatory to prevent skin/eye contact and inhalation. Work areas must be well-ventilated, and spills should be neutralized with oxidizing agents (e.g., hydrogen peroxide). Long-term storage demands inert gas blankets and temperatures below 25°C. Containers must be sealed tightly to minimize air exposure. Compatibility checks are essential—avoid contact with strong oxidizers, acids, or metals prone to catalyzing decomposition.
B2B Procurement Guide
Industrial buyers should prioritize suppliers with ISO-certified production facilities to ensure consistency. Key specifications include purity (≥95%, verified by GC), water content (<0.1%), and peroxide levels. Bulk orders (drum/tanker quantities) often reduce costs by 15–30%. Request batch-specific Certificates of Analysis (CoA) and evaluate logistics options—some vendors offer stabilized packaging for international shipping. Sample testing is recommended to confirm compatibility with end-use processes. For nanotechnology applications, ultra-high purity grades (≥99%) may be necessary.
Related Manufacturers
- 主营：甲基丙烯酸十二酯、甲基丙烯酸十六酯、甲基丙烯酸十八酯、N-乙酰己内酰胺、N-异丙基丙烯酰胺、丙烯酸十二酯、丙烯酸十六酯、丙烯酸十八酯、V50引发剂、偶氮二异丁咪唑啉盐酸盐、硅烷偶联剂、双马来酰亚胺、马来酸酯、缩水甘油酯、缩水甘油醚、甲基咪唑、金属萃取剂
- 主营：全氟三丁胺、全氟三乙胺、全氟三丙胺、己二硫醇、全氟聚醚、全氟萘烷、全氟己酮、羟基磷灰石、生物活性玻璃、布洛芬、溴壬烷、磷酸铵、甲乙基、褪黑素、嘧啶钠、莪术油、显色剂、叔丁醇、茜素红、乙氧基、异戊醇、脯氨酸、茚三酮、氯唑沙
- 主营：2-十一酮、乙酸龙脑酯、聚苯乙烯磺酸钠、乙基黄原酸钾
- 主营：硫酸钡、覆盆子酮、胍基丙酸、己二硫醇现货供应、早强防冻剂、食品级磷酸镁、二肌酸苹果酸、苯基膦酰二氯、食品级硫酸镁、二肌酸柠檬酸
- 主营：钛酸酯、阻燃剂、催化剂、彩色显影剂 CD-3、彩色显影剂 CD-4、L-丙交酯、邻苯三酚、左旋樟脑磺酸、右旋樟脑磺酸、三碘化硼、纳斯特试剂
- 主营：花生酸、碳酸钠、单氟磷酸钠、丁基羟基茴香醚、鱼大豆酵母原料
- 主营：叔碳酸、十八醛、溶菌酶、2-甲基丁醛、10-羟基羊蜡酸、海藻糖、癸二醇、氨基丙基、氢路噻嗪、邻苯二甲、乙基碳二、羟基癸酸、正十七烷、谷胱甘肽、烷二甲醇、松果体素、vc磷酸酯镁、朱栾倍半萜、丁烷四乙酸、表面活性剂、癸烷撑二醇、缩水甘油邻、氢氯噻嗪杂质、盐酸邻菲罗啉、壳聚糖季铵盐
- 主营：丙烯酸单体、全氟三丁胺、甲基丙烯酸十八酯、1191、乙二醇二缩水甘油醚、催化剂、催干剂、环氧稀释剂、增塑剂、偶联剂、交联剂、橡胶塑料助剂、电镀电子科技材料、丙烯酸酯类
- 主营：有机原料、中间体、香精香料、催化剂、有机硅、表面活性剂
- 主营：甘氨酸、水苏糖、阻燃剂、1680-21-3、硫酸锌、硫酸锆、硫酸锂、硫酸锶、硫酸锰、铝酸锌、牛磺酸、褪黑素、磷酸铁、丙酸铵、苏云金、碳酸镁、麝香酮、肉桂醛、磷酸铝、王浆酸、椰油胺、赖氨酸、增塑剂、浸膏粉、乙氧基
- 主营：全氟三丁胺、二苄叉山梨醇、六氟丙烯二聚体、16、六氟环氧丙烷二聚体、异丙醇铝、纳米勃姆石、二异戊基硫醚、隐色结晶紫、邻菲罗啉
- 主营：杜仲素、对位酯、丙烯酸酯、16、二氧化硫脲、乙基麦芽酚、饲料添加剂、油酸基硬脂酸、二苯基硅二醇
- 主营：高铁酸钾
- 主营：三硫代碳酸钠、聚乙烯亚胺、三乙二醇二异辛酸酯、红色素-16、L-丙交酯、石油酯-T50、巯基苯并噻唑钠、乙交酯、多元醇苯甲酸酯、热压敏染料、光稳定剂、高分子降解材料
- 主营：1191、化工中间体、生物缓冲剂、实验试剂助剂