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Updated: 2026-07-19

Overview

1,3,5-Trimethylbenzene, also known as mesitylene, is a derivative of benzene with three methyl groups symmetrically arranged around the benzene ring. It is a clear, colorless liquid with a characteristic aromatic odor. Due to its high stability and solvent properties, it is widely used in industrial applications, particularly in organic synthesis and as a precursor for more complex chemical compounds. Mesitylene is produced through the alkylation of benzene or toluene and is a common component in petroleum refining streams. Its symmetrical structure makes it a valuable intermediate in the production of dyes, resins, and other specialty chemicals.

Physical and Chemical Properties

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1,3,5-Trimethylbenzene exhibits typical aromatic hydrocarbon properties, including a high degree of stability and resistance to oxidation under normal conditions. It has a boiling point of 164.7 °C and a melting point of -44.8 °C, making it a liquid at room temperature. The compound is insoluble in water but mixes well with most organic solvents, such as ethanol and ether. Its density of 0.865 g/cm³ is lower than water, and it has a flash point of 44 °C, classifying it as a flammable liquid. Mesitylene is relatively non-reactive under standard conditions but can undergo typical aromatic substitution reactions, such as nitration and sulfonation, under appropriate conditions.

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Main Applications

Mesitylene is primarily used as a solvent in various industrial processes, including the manufacture of paints, coatings, and adhesives. Its ability to dissolve a wide range of organic compounds makes it valuable in chemical synthesis and laboratory applications. In addition to its role as a solvent, 1,3,5-trimethylbenzene serves as a precursor in the production of dyes, resins, and pharmaceuticals. It is also used in the synthesis of more complex aromatic compounds, such as mesitylene oxide, which finds applications in fragrances and flavorings.

Safety and Storage

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1,3,5-Trimethylbenzene is a flammable liquid and should be stored in a cool, well-ventilated area away from heat sources and open flames. Proper grounding of containers is essential to prevent static discharge, which could ignite vapors. The compound can cause irritation to the skin, eyes, and respiratory tract, so appropriate personal protective equipment (PPE) such as gloves and goggles should be used when handling. In case of spills, absorb the material with an inert substance like sand or vermiculite and dispose of it in accordance with local regulations. Avoid releasing the chemical into the environment, as it can be harmful to aquatic life.

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B2B Procurement Guide

When procuring 1,3,5-trimethylbenzene, buyers should prioritize suppliers with a proven track record of delivering high-purity (≥98%) products. Certificates of analysis (CoA) should be requested to verify the chemical's purity and composition. Packaging options typically include drums or bulk containers, depending on the order volume. Transportation logistics should comply with local and international regulations for flammable liquids. Buyers should also consider the supplier's ability to provide technical support and safety data sheets (SDS) to ensure safe handling and storage practices.

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