13-Hydroxyberberine

Updated: 2026-09-19

Overview

13-Hydroxyberberine is a hydroxylated derivative of berberine, a well-known isoquinoline alkaloid found in plants like Berberis vulgaris. It has garnered interest in pharmaceutical and nutraceutical research due to its potential bioactive properties. Unlike berberine, 13-Hydroxyberberine features an additional hydroxyl group, which may enhance its solubility and biological activity. This compound is primarily studied for its potential therapeutic effects, including antioxidant, anti-inflammatory, and antimicrobial properties. While it is not as widely commercialized as berberine, its unique structure makes it a subject of ongoing scientific investigation.

Physical and Chemical Properties

13-Hydroxyberberine is a yellow to orange crystalline powder with a molecular weight of 352.36 g/mol. Its molecular formula, C20H18NO5, includes a hydroxyl group at the 13-position, distinguishing it from berberine. The compound is soluble in organic solvents such as methanol and ethanol but has limited solubility in water. Key chemical properties include its stability under controlled storage conditions and its potential to form salts with acids. These characteristics are critical for its formulation in pharmaceutical applications. Analytical methods like HPLC and mass spectrometry are commonly used to verify its purity and structure.

Main Applications

The primary application of 13-Hydroxyberberine lies in pharmaceutical research, where it is studied for its potential health benefits. Preliminary studies suggest it may exhibit antioxidant and anti-inflammatory effects, making it a candidate for treating metabolic and inflammatory conditions. Additionally, it is explored as an ingredient in dietary supplements and traditional medicine formulations. Its structural similarity to berberine allows it to be used in comparative studies to understand the impact of hydroxylation on bioactivity. However, commercial applications remain limited pending further clinical validation.

Safety and Storage

13-Hydroxyberberine should be handled with standard laboratory precautions to avoid inhalation or skin contact. Proper personal protective equipment (PPE), such as gloves and goggles, is recommended. The compound should be stored in a cool, dry place, protected from light and moisture to maintain stability. While toxicity data is limited, it is advisable to consult safety data sheets (SDS) and adhere to local regulations for handling bioactive alkaloids. Disposal should follow environmentally safe practices to prevent contamination.

B2B Procurement Guide

For B2B buyers, sourcing 13-Hydroxyberberine requires careful consideration of purity, supplier reliability, and compliance with regulatory standards. Bulk procurement may involve custom synthesis, so partnering with specialized chemical manufacturers is advisable. Key procurement factors include verifying analytical certificates (e.g., HPLC purity reports) and ensuring the supplier adheres to Good Manufacturing Practices (GMP). Pricing varies based on quantity and purity, so obtaining multiple quotes is recommended. Long-term supply agreements may be necessary for consistent availability.