Overview
4-Chloro-3-methylphenol (PCMC) is a chlorinated derivative of cresol, primarily valued for its antimicrobial properties. It is commonly used as a preservative in pharmaceuticals, cosmetics, and industrial products to prevent microbial growth. Its effectiveness against bacteria and fungi makes it a preferred choice in formulations requiring long-term stability. The compound is synthesized through the chlorination of 3-methylphenol (m-cresol). Its low volatility and stability under normal conditions enhance its suitability for various applications. Regulatory bodies such as the FDA and EPA have approved its use in specific concentrations, ensuring its safety for intended purposes.
Physical and Chemical Properties
PCMC is a white to off-white crystalline powder with a characteristic phenolic odor. It has a molecular weight of 142.58 g/mol and a density of 1.19 g/cm³. The compound melts at 64-66 °C and boils at 235-236 °C, indicating its stability under moderate temperatures. Solubility is a key factor in its application; PCMC dissolves well in organic solvents like ethanol and ether but is only slightly soluble in water. This property influences its formulation in aqueous or solvent-based systems. Its antimicrobial activity is pH-dependent, with higher efficacy in slightly acidic to neutral environments.
Main Applications
PCMC is widely used as a preservative in pharmaceuticals, including injectables, ointments, and oral medications. Its ability to inhibit microbial growth extends the shelf life of these products. In cosmetics, it is found in creams, lotions, and shampoos to prevent spoilage. Industrial applications include adhesives, paints, and textiles, where it acts as a biocide. Its use in disinfectants and sanitizers is also notable, particularly in healthcare settings. The compound's broad-spectrum activity makes it versatile, though concentration limits are regulated to ensure safety.
Safety and Storage
PCMC is classified as harmful if swallowed or inhaled and can cause skin and eye irritation. Proper personal protective equipment (PPE), such as gloves and goggles, is recommended during handling. Adequate ventilation is essential to avoid inhalation exposure. Storage requires a cool, dry environment away from oxidizing agents to prevent degradation. Containers should be tightly sealed and labeled according to GHS standards. Spills should be contained and cleaned promptly using appropriate absorbents, with disposal following local regulations.
B2B Procurement Guide
When procuring PCMC, buyers should prioritize suppliers who provide detailed technical data sheets (TDS) and safety data sheets (SDS). Verification of the CAS number (59-50-7) ensures product authenticity. Purity specifications, typically 98-99%, should align with intended use. Bulk purchases often offer cost advantages, but storage capacity and shelf life must be considered. Sample testing is advisable to confirm quality before large-scale procurement. Compliance with regional regulations, such as REACH in the EU, is critical to avoid legal and operational risks.
Related Manufacturers
- 主营：柱塞泵、打孔机、加热器、相机光源、同轴光源、环形光源、直线光源、频闪电源、高压钠灯、ir系列光源、旋转粘度计、大功率射灯、金属卤素灯、反射形光源、测温电阻体、耐温电阻器、线性漫射灯、数显粘度计、直线照明光源、同轴落射照明、高亮度点光源、tsubosakaled光源、lldhbc系列光源、显微镜卤素灯泡
- 主营：STRIKO爆破片、BIG Kaiser、behlke开关
- 主营：厚度计、压线钳、分析仪、深度表、测量仪、除草机、送液泵、记录器、微型钳、润滑器、风淋室、喷漆枪、热饭器、热电偶、预热板、扫描仪、电动钳、研磨机、钻孔机、探测机、冷却器、球关节、条连杆、计数秤、铁量仪
- 主营：欧姆龙、处理器、控制器、108、驱动器、eta钰泰、通信模块、集成电路、控制芯片、电源管理、电源负载、RTL
- 主营：毛刺机、滚筒机、提料机、抽粪机、上料机、分离机、橡胶皮、卸料机、磨光机、柚子粉、打磨机、送料机、研磨机、输送机、加料机、传送机、搅拌管、吸料机、地钻机、加湿机、抽料机、爬坡机、传送带、加药机、抛光机
- 主营：接收机、调频棒、合路器、光模块、光端机、频光模、传感器、信号覆、对讲机、安防监控、信号处理、调频天线、微波链路、机箱设计、射频光纤、智能芯片、传输设备、光收发器、雷达信号、广播系统、广电光纤、时钟模块、无线话筒、光发射机、切换开关
- 主营：电子硬件产品测试仪器、示波器、示波器探头、直流电子负载、可编程直流电源、网络分析仪、电池模拟器、频谱信号分析仪、安规测试仪、逻辑分析仪、源表SMU、万用表、函数发生器、阻抗分析仪、LCR数字电桥、数据采集器、温度记录仪
- 主营：阻燃剂、弯曲机、压槽机、氯化镁、衬塑管、阻燃阻、切管机、挤压机、潜孔钻、沟槽机、氯化钙、滚槽机、割管机、地钻机、防火阻、阻化剂、开孔器、钻孔机、74含量阻、钻孔设备、煤自燃阻、水磨石机、岩石钻机、防灭火阻、注浆钻机
- 主营：108、变压器、amphenol连接器、电子pomona连接器
- 主营：凿毛机、铣刨机、阻化剂、冷弯机、钢管滚槽机、钢管缩管机、岩石分裂机、岩石劈裂机、钢筋镦粗机、双缸镦粗机、350mm水磨石机、skd70潜孔钻机、混凝土劈裂机、隧道潜孔钻机、井下潜孔钻机、工字钢弯曲机、钢筋冷挤压机、锚杆潜孔钻机、钢绞线穿束机、电动潜孔钻机、气动潜孔钻机、工字钢弯拱机、小型沥青灌缝机、全液压潜孔钻机、多功能潜孔钻机
- 主营：泵泵头、凸轮盘、91y泵头、泵柱塞、电磁阀、现代suv、出油阀、高压泵、测试台、缸泵头、p84编号、喷油器、传感器、增压阀、7183-125l、博世阀、研磨机、共轨阀、阀组件、传动轴、十字块、泄压阀、调压阀、帕金斯、suv柱塞