Overview
1-Hydroxyvalerenic Acid is a naturally occurring sesquiterpenoid derived from Valeriana officinalis (valerian root). It is structurally related to valerenic acid, a compound studied for its potential neuropharmacological effects. The hydroxyl group at the 1-position enhances its polarity and may influence its bioavailability. This compound is primarily of interest in academic and industrial research, particularly in the development of herbal medicines targeting anxiety and sleep disorders. Its extraction and synthesis require specialized techniques due to its low natural abundance.
Physical and Chemical Properties
1-Hydroxyvalerenic Acid appears as an off-white crystalline powder with a melting point range of 120-125°C. Its molecular formula (C15H22O3) reflects a sesquiterpenoid backbone with a carboxylic acid and hydroxyl functional group. The compound exhibits limited water solubility but dissolves readily in polar organic solvents like ethanol or dimethyl sulfoxide (DMSO). Stability tests suggest it degrades under prolonged exposure to UV light or high temperatures, necessitating dark, cold storage.
Main Applications
In pharmaceuticals, 1-Hydroxyvalerenic Acid is investigated for its potential role in modulating GABA receptors, akin to its parent compound valerenic acid. This mechanism may contribute to anxiolytic or sedative effects, though clinical evidence remains preliminary. It is also used as a reference standard in analytical chemistry to quantify valerian-derived products. Herbal supplement manufacturers may incorporate it into formulations targeting stress relief, though regulatory approval varies by region.
Safety and Storage
While classified as low-risk, 1-Hydroxyvalerenic Acid should be handled with standard lab precautions: gloves, goggles, and ventilation. No severe toxicity data is available, but ingestion or inhalation of powder should be avoided. Long-term stability requires storage in amber glass vials at 2-8°C, ideally under inert gas (e.g., argon) to prevent oxidation. Bulk quantities may require desiccants to mitigate moisture absorption.
B2B Procurement Guide
B2B buyers should prioritize suppliers that provide third-party purity certification (e.g., HPLC ≥95%). Batch-specific Certificates of Analysis (COA) are essential for research-grade material. Pricing varies significantly with purity and scale; bulk orders (100+ grams) often qualify for discounts. Due to niche demand, lead times may extend to 4-6 weeks. Consider vendors compliant with Good Manufacturing Practice (GMP) for pharmaceutical applications.
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