1-Chlorohexane[2]

Updated: 2026-09-15

Overview

1-Chlorohexane, also known as hexyl chloride, is an organic halide with the molecular formula C6H13Cl. It is a colorless, volatile liquid with a characteristic odor. This compound is primarily used as an intermediate in the synthesis of other chemicals, including pharmaceuticals, agrochemicals, and surfactants. Its reactivity and solubility in organic solvents make it valuable in various industrial processes. 1-Chlorohexane is produced through the chlorination of n-hexane or the hydrochlorination of 1-hexene. The compound is classified as a hazardous substance due to its flammability and potential health effects, necessitating careful handling and storage.

Physical and Chemical Properties

1-Chlorohexane is a colorless liquid with a density of approximately 0.88 g/cm³ at 20°C. It has a melting point of -94°C and a boiling point of 134-135°C. The compound is insoluble in water but miscible with most organic solvents, including ethanol, ether, and benzene. Its volatility and flammability require precautions to avoid exposure to open flames or high temperatures. The chemical reactivity of 1-chlorohexane includes its ability to participate in nucleophilic substitution reactions, making it a useful intermediate in organic synthesis. It reacts with strong oxidizing agents and can decompose under certain conditions, releasing toxic gases such as hydrogen chloride.

Main Applications

1-Chlorohexane is widely used as an intermediate in the production of pharmaceuticals, agrochemicals, and specialty chemicals. It serves as a precursor in the synthesis of hexyl derivatives, which are employed in surfactants, lubricants, and plasticizers. The compound is also utilized as a solvent in certain industrial processes due to its ability to dissolve a variety of organic materials. In the pharmaceutical industry, 1-chlorohexane is used to produce active pharmaceutical ingredients (APIs) and other intermediates. Its role in agrochemical synthesis includes the manufacture of herbicides and pesticides. Additionally, it finds applications in the production of dyes, fragrances, and other fine chemicals.

Safety and Storage

1-Chlorohexane is classified as a hazardous substance due to its flammability and potential health effects. It can cause skin and eye irritation upon contact and is harmful if inhaled or ingested. Proper personal protective equipment (PPE), including gloves, goggles, and respirators, should be used when handling this chemical. Storage of 1-chlorohexane requires a cool, dry, well-ventilated area away from heat sources and open flames. Containers should be tightly sealed to prevent evaporation and contamination. In case of a spill, absorb the liquid with an inert material and dispose of it in accordance with local regulations. Emergency procedures should include ventilation and the use of appropriate fire-extinguishing agents.

B2B Procurement Guide

When procuring 1-chlorohexane, it is essential to verify the supplier's compliance with safety and quality standards. Request a Safety Data Sheet (SDS) to ensure proper handling and storage guidelines are followed. The purity of the compound should be confirmed through certificates of analysis (CoA) to meet the specific requirements of your application. Bulk purchases may offer cost advantages, but storage capacity and shelf life should be considered. Establish a reliable supply chain to avoid disruptions in production. For international procurement, ensure compliance with transportation regulations for hazardous materials. Always compare prices from multiple suppliers to secure competitive rates.