Overview
1-(5-Hydroxy-2-pyrimidinyl)piperazine is a heterocyclic organic compound combining a pyrimidine and piperazine moiety. It serves as a key building block in medicinal chemistry, particularly for synthesizing bioactive molecules. The compound's structure allows for modifications to enhance drug-like properties, making it valuable for research and industrial applications. Due to its role as an intermediate, it is typically handled in controlled environments by professionals. Its synthesis requires specialized knowledge of organic reactions, and commercial availability is limited to suppliers catering to pharmaceutical and research sectors.
Physical and Chemical Properties
The compound appears as a white to off-white crystalline powder with moderate solubility in polar organic solvents. Its molecular weight of 180.21 g/mol and formula (C8H12N4O) reflect a balanced hydrophilicity-lipophilicity profile, suitable for drug design. Thermal stability data (melting/boiling points) are often proprietary but generally align with similar piperazine derivatives. Solubility is a critical factor for its utility; it dissolves well in DMSO and ethanol but has limited water compatibility. This property guides its use in solvent-based reaction systems. Stability under ambient conditions is adequate, though prolonged exposure to light or humidity may degrade the compound.
Main Applications
1-(5-Hydroxy-2-pyrimidinyl)piperazine is primarily employed in pharmaceutical R&D, particularly for antiviral and antibacterial agents. Its structure is amenable to functionalization, enabling the creation of novel therapeutic candidates. For instance, it may serve as a precursor for kinase inhibitors or antimicrobial scaffolds. Beyond pharmaceuticals, the compound finds niche use in agrochemical research and specialty chemical synthesis. However, its adoption is constrained by cost and the need for precise handling, limiting large-scale industrial applications.
Safety and Storage
Handling requires standard laboratory precautions: use fume hoods, nitrile gloves, and safety goggles. Although toxicity data are incomplete, assume potential irritancy to skin, eyes, and respiratory systems. Spills should be contained with inert absorbents and disposed of as hazardous waste. Storage demands airtight containers under inert gas (e.g., nitrogen) to prevent oxidation. Temperature should be maintained below 25°C, with desiccants to mitigate moisture uptake. Shelf life is typically 1-2 years when stored correctly, though batch-specific stability testing is advised.
B2B Procurement Guide
Procurement focuses on purity (≥98% by HPLC), supplier reliability, and documentation. Request certificates of analysis (COA) detailing impurities, residual solvents, and spectroscopic validation (NMR, MS). Reputable suppliers should provide material safety data sheets (MSDS) compliant with GHS standards. Bulk purchases (100g+) may qualify for discounts, but validate scalability with pilot batches. Lead times vary; specialty chemicals often require 4-8 weeks for synthesis and QC. Consider regional regulations—some jurisdictions restrict import/export of piperazine derivatives.
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