Overview
1-(2,4-Dichlorophenyl)ethylamine is an organic compound featuring an amine group attached to a dichlorophenyl ring. It serves as a versatile intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound’s structure allows for further functionalization, making it valuable in fine chemical manufacturing. Due to its reactive amine group, it is often used in amidation or alkylation reactions. Industrial demand is driven by its role in producing active pharmaceutical ingredients (APIs) and crop protection agents. Suppliers typically offer it in liquid form with high purity grades.
Physical and Chemical Properties
This compound is a colorless to pale yellow liquid at room temperature, with moderate solubility in polar organic solvents like ethanol and acetone. Its molecular weight of 190.07 g/mol and amine functionality contribute to its reactivity in nucleophilic substitution reactions. The dichlorophenyl moiety enhances its stability under typical storage conditions, though it should be protected from prolonged exposure to light and moisture. Key chemical properties include its basicity (pKa ~9–10) and susceptibility to oxidation, necessitating inert atmosphere storage for long-term preservation.
Main Applications
1-(2,4-Dichlorophenyl)ethylamine is primarily used in pharmaceutical synthesis, particularly for antihistamines and antifungal agents. Its dichlorophenyl group is a common pharmacophore in drug design, contributing to binding affinity and metabolic stability. In agrochemicals, it acts as a precursor for herbicides and fungicides. The compound’s versatility also extends to research applications, where it serves as a building block for novel organic molecules. Industrial-scale procurement is common among specialty chemical manufacturers.
Safety and Storage
The compound requires careful handling due to its potential irritant effects. Personal protective equipment (PPE), including nitrile gloves and safety goggles, is mandatory during use. Avoid inhalation of vapors and ensure adequate ventilation in workspaces. Storage recommendations include keeping the liquid in amber glass bottles under nitrogen or argon to prevent degradation. Label containers clearly and segregate from strong oxidizers. Spills should be neutralized with absorbent materials and disposed of as hazardous waste.
B2B Procurement Guide
When sourcing 1-(2,4-Dichlorophenyl)ethylamine, prioritize suppliers with ISO 9001 certification and documented quality control processes. Request certificates of analysis (CoA) to verify purity (typically ≥98%) and impurity profiles. Bulk pricing is often negotiable for orders exceeding 100 kg. Consider logistical factors such as temperature-controlled shipping for international purchases. Establish long-term contracts with reliable suppliers to ensure consistent quality and avoid supply chain disruptions.
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