Overview
1-(2-Hydroxyethyl)pyrrole is an organic compound featuring a pyrrole ring substituted with a hydroxyethyl group. It is widely used as an intermediate in pharmaceutical and chemical synthesis due to its reactive functional groups. The compound is typically a colorless to pale yellow liquid with a distinct odor. Its molecular structure combines the aromatic properties of pyrrole with the reactivity of a hydroxyl group, making it versatile for various chemical reactions. This dual functionality allows it to participate in condensation, alkylation, and other organic transformations.
Physical and Chemical Properties
1-(2-Hydroxyethyl)pyrrole is a moderately polar liquid with a density of approximately 1.04 g/cm³. It is soluble in water and most organic solvents, including ethanol, acetone, and dichloromethane. The compound's boiling point ranges between 220-225 °C, and it exhibits stability under standard storage conditions. The presence of both hydroxyl and pyrrole groups imparts unique reactivity. The hydroxyl group can undergo esterification or etherification, while the pyrrole ring can participate in electrophilic substitution reactions. These properties make it valuable for synthesizing complex organic molecules.
Main Applications
1-(2-Hydroxyethyl)pyrrole is primarily used as a building block in pharmaceutical synthesis. It serves as an intermediate for drugs targeting neurological and cardiovascular conditions. Additionally, it is employed in agrochemical production and specialty chemical manufacturing. In research, this compound is utilized to develop novel heterocyclic compounds. Its reactivity enables the creation of polymers and coatings with tailored properties. The versatility of 1-(2-Hydroxyethyl)pyrrole makes it indispensable in advanced organic chemistry applications.
Safety and Storage
Handling 1-(2-Hydroxyethyl)pyrrole requires caution due to its potential irritant effects. Proper personal protective equipment (PPE), including gloves and goggles, should be worn. The compound should be stored in a cool, dry place away from oxidizing agents and direct sunlight. In case of skin contact, rinse immediately with water. For eye exposure, flush with water for at least 15 minutes and seek medical attention. Ensure adequate ventilation in storage and workspaces to prevent vapor accumulation.
B2B Procurement Guide
When procuring 1-(2-Hydroxyethyl)pyrrole, verify the supplier's certification and product specifications. Request detailed technical data sheets (TDS) and material safety data sheets (MSDS). Bulk purchases may offer cost advantages, but ensure the supplier can meet quality and delivery timelines. Compare prices from multiple suppliers, as rates vary based on purity and quantity. Consider logistics and storage requirements, especially for large orders. Establish a reliable supply chain to avoid disruptions in production processes.
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